gon-2 Antibody

Code CSB-PA835914XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans gon-2 Polyclonal antibody
Uniprot No.
Target Names
gon-2
Alternative Names
gon-2 antibody; T01H8.5/T01H8.3/T01H8.4 antibody; Transient receptor potential channel antibody; Abnormal gonad development protein 2 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans gon-2 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Required for initiation and continuation of postembryonic mitotic cell divisions of gonadal cells Z1 and Z4. Zygotic expression is necessary for hermaphrodite fertility. May be a cation channel.
Gene References into Functions
  1. the activity of GTL-2 balances the activities of the paralogous TRPM channel proteins, GON-2 and GTL-1 PMID: 20221407
  2. PIP(2)-dependent regulation of GON-2/GTL-1 may provide a mechanism to coordinate plasma membrane Ca(2+) influx with PLCgamma and IP(3) receptor activity as well as intracellular Ca(2+) store depletion. PMID: 19923421
  3. Inactivation of gem-1 enhances the gonadogenesis defects of gon-2 hypomorphic mutations, suggesting that these two genes probably act in parallel to promote gonadal cell divisions. PMID: 19087963
Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
Transient receptor (TC 1.A.4) family, LTrpC subfamily
Tissue Specificity
Gonads.
Database Links

KEGG: cel:CELE_T01H8.5

STRING: 6239.T01H8.5a

UniGene: Cel.19771

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