Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TRX2 Polyclonal antibody

Uniprot No.

P22803

Target Names

TRX2

Alternative Names

TRX2 antibody; TRX1 antibody; YGR209C antibody; G7746Thioredoxin-2 antibody; Thioredoxin II antibody; TR-II antibody; Thioredoxin-1 antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TRX2 protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl-hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism. Through its capacity to inactivate the stress response transcription factor YAP1 and its regulator the hydroperoxide stress sensor HYR1, it is involved in feedback regulation of stress response gene expression upon oxidative stress.

Gene References into Functions

In fibroblasts from TRX2 deficiency patient, an important role for reactive oxygen species was found for neuronal maintenance. PMID: 26626369
Trx2p is a new positive effector in the regulation of the Skn7p transcription factor that controls phosphorylation events and, modulates the oxidative stress response in yeast. PMID: 24376879
Trx2 is required for maintaining the redox status in Saccharomyces cerevisiae under conditions of physiological stress. PMID: 23416294
TRX2 is required to maintain the IMS small Tim proteins in reduced forms and facilitate their mitochondrial import PMID: 22878414
Overexpression of TRX2 gene reduced oxidative cellular damage. PMID: 20152017

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Subcellular Location

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus.

Protein Families

Thioredoxin family

Database Links

KEGG: sce:YGR209C

STRING: 4932.YGR209C

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TRX2 Antibody

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