TRR1 Antibody

Code CSB-PA025388XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TRR1 Polyclonal antibody
Uniprot No.
Target Names
TRR1
Alternative Names
TRR1 antibody; YDR353W antibody; D9476.5 antibody; Thioredoxin reductase 1 antibody; EC 1.8.1.9 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TRR1 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Acts on thioredoxins 1 and 2.
Gene References into Functions
  1. In searching for spontaneous suppressors of synthetic lethality of tsa1Delta rad51Delta double mutants, we identified that the loss of thioredoxin reductase Trr1 rescues their viability. PMID: 25247923
  2. The cytosolic thioredoxin-thioredoxin reductase system and not the glutaredoxins contributes to the reduction of GSSG PMID: 19951944
  3. The iron-binding activity of thioredoxin reductase was identified. PMID: 18406344
  4. the crystal structure of Trr1 at the resolution of 2.8 A, the first fungal TrxR structure PMID: 18930846
  5. Results suggest that redox control via the thioredoxin-thioredoxin reductase 1/2 system plays an important role in the regulation of translation. PMID: 19622355

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Subcellular Location
Cytoplasm. Mitochondrion intermembrane space.
Protein Families
Class-II pyridine nucleotide-disulfide oxidoreductase family
Database Links

KEGG: sce:YDR353W

STRING: 4932.YDR353W

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