TUP1 Antibody

1. Tup1 regulates GAL1 epigenetic transcriptional memory. Tup1 is necessary for incorporation of both H2A.Z and H3K4me2 at the GAL1 promoter. PMID: 28607146
2. we identified a transposable element insertion in the promoter region of known flocculation gene FLO1, and, in an additional five clones, we recovered loss-of-function mutations in transcriptional repressor TUP1, which regulates FLO1 and other related genes PMID: 28450459
3. CYC8 and TUP1 were required for transcription of the amino acid transporter genes. PMID: 26546823
4. coordinated sumoylation of Gcn4, Tup1 and likely other factors dampens activated transcription by stabilizing Tup1 binding and stimulating Gcn4 and RNAP II removal PMID: 25766875
5. These data suggest that distinctly bound Cyc8-Tup1 cooperates with Hda1p and Rpd3p to establish or maintain an extensive array of strongly positioned, deacetylated nucleosomes over the FLO1 promoter and upstream region which inhibit histone acetylation, block Swi-Snf binding and prevent transcription. PMID: 25106892
6. Data indicate that Tup1 and the metabolic enzymes that control PI(3,5)P2 are highly conserved among eukaryotes. PMID: 23733183
7. data presented herein highlight the importance of the architecture of the Tup1p N-terminal domain for self-association PMID: 22707714
8. Cyc8-Tup1 regulates transcription primarily by masking and inhibiting the transcriptional activation domains of the recruiting proteins, not by acting as a corepressor PMID: 22156212
9. Analysis of wild-type and tup1 Delta chromatin data sets revealed unique organizational themes relating to the function of Tup1. PMID: 21785133
10. Tup1--which associates with multiple transcriptional regulators, including the HDAC (histone deacetylase) and SAGA complexes--plays a crucial role in determining an activated or repressed chromatin state of numerous genes, including GAL1. PMID: 21536737
11. Ssn6-Tup1 requires ISW2 complex to position nucleosomes. PMID: 15116071
12. Hda1 partially represses roughly 30% of Tup1-repressed genes, whereas Srb10 kinase activity contributes to the repression of approximately 15% of Tup1-repressed genes. PMID: 15240822
13. A genome-wide analysis was made of the functions of a conserved surface on the corepressor TUP1. PMID: 15788561
14. Transcription in the absence of heme required the presence of Cti6p to overcome the effect of Tup1p, and Cti6p was recruited to the ARN1 promoter in the absence of heme. PMID: 16437160
15. Data show that Htz1 is required for efficient Mediator recruitment and transcription only when the GAL1 promoter is under the influence of the Tup1 corepressor. PMID: 17387147
16. in the absence of Tup1, TPR1 is partially unfolded with its helix B being highly dynamic exposing an apolar surface to the solvent PMID: 17634984
17. in Srb10p derivatives, the absence of CM-1 & CM-II motifs decreases the interaction of Srb10p with its cyclin partner Srb11p and with the component Tup1p of the general co-repressor complex Tup1p-Ssn6p. PMID: 17689156
18. Chromatin immunoprecipitation analyses of the GRE2 promoter in the mutants demonstrated that the Sko1-Tup1-Cyc8 complex was localized to the promoter PMID: 18201562
19. analysis of functional links between the amino acids-sensing SPS system, the CUP9-TUP1-SSN6 repressor complex, the PTR2 peptide transporter, and the UBR1-dependent N-end rule pathway PMID: 18708352

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KEGG: sce:YCR084C

STRING: 4932.YCR084C