tutl Antibody

Code CSB-PA842620XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) tutl Polyclonal antibody
Uniprot No.
Target Names
tutl
Alternative Names
tutl antibody; CG15427 antibody; Protein turtle antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) tutl protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Essential protein that plays a role in the establishment of coordinated motor control. In the developing eye, involved in axonal targeting of the R7 photoreceptor.
Gene References into Functions
  1. Tutl interacts with Borderless (Bdl) in controlling R7 axonal tiling phenotype and may downregulate R7 axon-axon adhesion by interacting with Bdl. PMID: 24174674
  2. This study indicated that the turtle proteins function as axon guidance cues that promote midline attraction, axon branching, and axonal invasiveness. PMID: 19686588
  3. tutl gene is required to restrain dendrite branch formation in neurons with simple arbors, and to promote dendrite self-avoidance in neurons with complex arbors. PMID: 19783736
  4. Tutl controls R7 tiling by preventing fusion between adjacent R7 axons; it mediates homophilic cell-cell interactions; suggests Tutl-mediated terminal-terminal recognition functions in parallel to intrinsic growth control mediated by Activin pathway PMID: 19906964
Subcellular Location
Membrane; Single-pass membrane protein.
Protein Families
Immunoglobulin superfamily, Turtle family
Tissue Specificity
Exclusively expressed in the central nervous system.
Database Links

KEGG: dme:Dmel_CG15427

STRING: 7227.FBpp0305668

UniGene: Dm.1777

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