cat-2 Antibody

Code CSB-PA023470XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans cat-2 Polyclonal antibody
Uniprot No.
Target Names
cat-2
Alternative Names
cat-2 antibody; B0432.5 antibody; Tyrosine 3-monooxygenase antibody; EC 1.14.16.2 antibody; Abnormal catecholamine distribution protein 2 antibody; Tyrosine 3-hydroxylase antibody; TH antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans cat-2 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in the synthesis of catecholamines, such as dopamine. Has a role in serotonin signaling. Required for normal explorative and foraging behavior. In response to food, involved in promoting the dopamine-mediated suppression of crh-1/CREB1 transcription factor activation in cholinergic SIA neurons. Modulates male mating behavior by controlling the protrusion of copulatory spicules from the tail of males during hermaphrodite vulval location.
Gene References into Functions
  1. Knocking-down of cat-2 led to increase in aggregation of alpha synuclein; the silencing of cat-2 had significant effects on associated endpoints including oxidative stress, lipid content and neurotransmission. PMID: 22483307
  2. These data suggest that the intricate regulation characteristic of mammalian TH might have evolved from more simple models to adjust to the increasing complexity of the higher eukaryotes neuroendocrine systems. PMID: 21087208
Subcellular Location
Cytoplasm, perinuclear region.
Protein Families
Biopterin-dependent aromatic amino acid hydroxylase family
Tissue Specificity
Expressed in dopaminergic cells. Expressed in neurons in the head and middle body of the hermaphrodite, and six neurons in the tail of the male.
Database Links

STRING: 6239.B0432.5

UniGene: Cel.8024

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