thyA Antibody

Datasheet

Code	CSB-PA025393XA01ENV
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Product Details

Full Product Name

Rabbit anti-Escherichia coli (strain K12) thyA Polyclonal antibody

Uniprot No.

P0A884

Target Names

thyA

Alternative Names

thyA antibody; b2827 antibody; JW2795 antibody; Thymidylate synthase antibody; TS antibody; TSase antibody; EC 2.1.1.45 antibody

Raised in

Rabbit

Species Reactivity

Escherichia coli (strain K12)

Immunogen

Recombinant Escherichia coli (strain K12) thyA protein

Immunogen Species

Escherichia coli (strain K12)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.

Gene References into Functions

The measured activities of the E. coli thymidylate synthase (TS) mutants imply that conservation of electrostatics in the region of the active site is important for the activity of TS. PMID: 26612036
Data indicate the BGC 945 formed complexes and inhibited E coli and human thymidylate synthase (TS). PMID: 23710599
findings suggested that Y94 is part of a H-bond network that plays a critical role at a step between the proton and the hydride transfers, presumably the dissociation of H4folate from the covalently bound intermediate. PMID: 17999469

Subcellular Location

Cytoplasm.

Protein Families

Thymidylate synthase family, Bacterial-type ThyA subfamily

Database Links

KEGG: ecj:JW2795

STRING: 316385.ECDH10B_2997

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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thyA Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background