let-70 Antibody

Code CSB-PA330425XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans let-70 Polyclonal antibody
Uniprot No.
Target Names
let-70
Alternative Names
let-70 antibody; ubc-2 antibody; M7.1 antibody; Ubiquitin-conjugating enzyme E2 2 antibody; EC 2.3.2.23 antibody; E2 ubiquitin-conjugating enzyme 2 antibody; Lethal protein 70 antibody; Ubiquitin carrier protein 2 antibody; Ubiquitin-protein ligase 2 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans let-70 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Plays a role in the DNA damage response. In particular, in response to ionizing radiation, associates with the E3 ubiquitin-protein ligase brc-1-brd-1 heterodimer on chromatin to activate E3-ubiquitin ligase activity of the heterodimer, and thus its DNA damage repair mechanisms. Required, cell autonomously, for death of the linker cell, a male-specific cell which guides the elongation of the gonad; perhaps acting as part of the ubiquitin proteasome system (UPS) and modulated by heat shock transcription factor hsf-1.
Gene References into Functions
  1. UBC-2 functions with the anaphase-promoting complex PMID: 15466891
Subcellular Location
Nucleus. Chromosome. Cytoplasm.
Protein Families
Ubiquitin-conjugating enzyme family
Tissue Specificity
Expressed in the nervous system.
Database Links

KEGG: cel:CELE_M7.1

STRING: 6239.M7.1.1

UniGene: Cel.18192

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