UBC24 Antibody

Code CSB-PA848739XA01DOA
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Product Details

Full Product Name
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) UBC24 Polyclonal antibody
Uniprot No.
Target Names
UBC24
Alternative Names
UBC24 antibody; PHO2 antibody; At2g33770 antibody; T1B8.8 antibody; Probable ubiquitin-conjugating enzyme E2 24 antibody; EC 2.3.2.23 antibody; AtPHO2 antibody; E2 ubiquitin-conjugating enzyme 24 antibody; Ubiquitin carrier protein 24 antibody; Ubiquitin-protein ligase 24 antibody
Raised in
Rabbit
Species Reactivity
Arabidopsis thaliana
Immunogen
Recombinant Arabidopsis thaliana UBC24 protein
Immunogen Species
Arabidopsis thaliana (Mouse-ear cress)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates PHO1 degradation through multivesicular body-mediated vacuolar proteolysis in response to inorganic phosphate (Pi) availability. Negatively regulates the protein abundance of PHF1 and PHT1s under Pi-sufficient conditions by facilitating the degradation of PHT1 proteins at the endomembrane.
Gene References into Functions
  1. PHR1 is a key factor for metabolic reprogramming during phosphorus (P) limitation. The effects of pho2 or microRNA399 overexpression were comparatively minor. PMID: 24894834
  2. NLA is an E3 ligase that specifically requires UBC24 for polyubiquitination in Arabidopsis thaliana. PMID: 24474629
  3. PHO2 negatively regulates the protein abundance of PHF1 and PHT1 proteins under Pi-sufficient conditions PMID: 24122829
  4. The phosphate-accumulating mutants siz1 and pho2 reduce the uptake and accumulation of Na(+), leading to enhanced salt tolerance, and that, genetically, SIZ1 and PHO2 are likely independent of SOS3-dependent salt signaling. PMID: 21748325
  5. PHO2-dependent degradation of PHO1 modulates phosphate homeostasis in Arabidopsis. PMID: 22634761
  6. Expression of TSF was increased in miR399b-overexpressing plants and pho2 mutants at 23 degrees C, suggesting that their early flowering phenotype is associated with TSF upregulation. PMID: 21533549
  7. A previously identified Pi overaccumulator, pho2, is caused by a single nucleotide mutation resulting in early termination within the UBC24 gene. PMID: 16679417
  8. Map-based cloning identified PHO2 as At2g33770. miR399 and PHO2 are in a branch of the Pi-signaling network downstream of PHR1. PMID: 16679424
  9. IPS1 overexpression results in increased accumulation of the miR-399 target PHO2 mRNA and, concomitantly, in reduced shoot Pi content; engineering of IPS1 to be cleavable abolishes its inhibitory activity on miR-399. PMID: 17643101

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Subcellular Location
Golgi apparatus membrane. Endoplasmic reticulum membrane.
Protein Families
Ubiquitin-conjugating enzyme family
Tissue Specificity
Expressed in the vascular tissues of cotyledons, leaves, roots, sepals, filaments, anthers and junctions between the inflorescence stems and siliques.
Database Links

KEGG: ath:AT2G33770

STRING: 3702.AT2G33770.1

UniGene: At.14693

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