Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) scny Polyclonal antibody

Uniprot No.

Q9VRP5

Target Names

scny

Alternative Names

scny antibody; Usp36 antibody; CG5505 antibody; Ubiquitin carboxyl-terminal hydrolase 36 antibody; EC 3.4.19.12 antibody; Deubiquitinating enzyme 36 antibody; Protein scrawny antibody; Ubiquitin thioesterase 36 antibody; Ubiquitin-specific-processing protease 36 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) scny protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Hydrolase that deubiquitinates polyubiquitinated target proteins including imd. Required for preventing the constitutive activation of the imd/NF-kappa-B (Imd) signaling cascade under unchalleneged conditions. Deubiquitinates imd linked 'Lys-63' chains which leads its proteasomal degradation and consequently down-regulation of the Imd signaling cascade. Removal of the activating 'Lys-63'-linked chains is likely to enable their replacement with 'Lys-48'-linked chains which act as 'tags' the for proteosomal degradation of imd. Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4me3). Controls selective autophagy activation by ubiquitinated proteins.

Gene References into Functions

specific inactivation in hemocytes renders susceptibility to L. monocytogenes infections PMID: 24777180
USP36 controls selective autophagy activation in Drosophila and in human cells. PMID: 22622177
The study describes Drosophila ubiquitin protease USP36/Scny function in innate immunity. USP36 is notably required in the gut and prevents constitutive activation of NF-kappaB signal by hydrolysing K63 ubiquitin chains on the adaptator molecule IMD. PMID: 19837371
study describes a Drosophila gene, scrawny (scny), encoding a ubiquitin-specific protease, which is required in germline, epithelial & intestinal stem cells; it deubiquitylates histone H2B and functions in gene silencing PMID: 19039105

Subcellular Location

Nucleus, nucleolus. Cytoplasm.

Protein Families

Peptidase C19 family

Database Links

KEGG: dme:Dmel_CG5505

STRING: 7227.FBpp0076806

UniGene: Dm.6825

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scny Antibody

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