ufd-1 Antibody

Code CSB-PA622159XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans ufd-1 Polyclonal antibody
Uniprot No.
Target Names
ufd-1
Alternative Names
ufd-1 antibody; F19B6.2 antibody; Ubiquitin fusion degradation protein 1 homolog antibody; UB fusion protein 1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans ufd-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Functions at a post-ubiquitination step in the ubiquitin fusion degradation (UFD) pathway. In association with npl-4.1 and/or npl-4.2 and ATPase cdc-48.1 and/or cdc-48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with npl-4.1 and/or npl-4.2, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CMG helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5. Regulates ubxn-3 nuclear localization during S phase.
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
UFD1 family
Database Links

KEGG: cel:CELE_F19B6.2

STRING: 6239.F19B6.2a

UniGene: Cel.22547

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