odr-8 Antibody

Code CSB-PA842436XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans odr-8 Polyclonal antibody
Uniprot No.
Target Names
odr-8
Alternative Names
odr-8 antibody; ufsp-2 antibody; F38A5.1 antibody; Ufm1-specific protease antibody; UfSP antibody; EC 3.4.22.- antibody; Odorant response abnormal protein 8 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans odr-8 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ufm-1, a ubiquitin-like modifier protein bound to a number of target proteins. Required, with oct-4, for the localization of a subset of 7 transmembrane domain odorant receptors, including odr-10, to the cilia of olfactory neurons AWA and AWC. Operates in aggregation behavior, and responses to oxygen levels.
Gene References into Functions
  1. There are two forms: UfSP1 and UfSP2, the later with an additional domain at the N-terminus. The crystal structure reveals that these additional residues display a MPN fold. The MPN domain does not have the metalloprotease activity found in some MPN-domain containing proteins, rather it is required for the recognition and deufmylation of the substrate. PMID: 27240952
Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasm. Cytoplasm, perinuclear region.
Protein Families
Peptidase C78 family
Tissue Specificity
Expressed in head and tail neurons. Expressed in the amphid head neurons ADL, ASI, ASH, ASJ, ASG, ADF, ASK, AWA, AWB, AWC, and in two tail neurons, the phasmid tail neurons PHA and PHB.
Database Links

KEGG: cel:CELE_F38A5.1

STRING: 6239.F38A5.1a

UniGene: Cel.23125

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