ULP1 Antibody

1. Detailed comparison of the SUMO-binding activity of the budding yeast protein Ulp1 (ScUlp1) and its ortholog in the thermotolerant yeast Kluyveromyces marxianus, KmUlp1. We find that the catalytic UD domains of both ScUlp1 and KmUlp1 show a high degree of sequence conservation, complement a ulp1Delta mutant in vivo, and process a SUMO precursor in vitro. PMID: 29351565
2. our data highlight a role for the NPC-associated SUMO protease Ulp1 in regulating the sumoylation of gene-bound transcription regulators. PMID: 24074957
3. A prominent ~50-kDa sumoylated protein accumulates in a Ulp1 coiled-coil domain mutant; that was identified as Scs2, an endoplasmic reticulum (ER) membrane protein that regulates phosphatidylinositol synthesis and lipid trafficking. PMID: 22025676
4. Data characterize a novel mode of SUMO system control: in response to elevated alcohol levels, the Saccharomyces cerevisiae SUMO protease Ulp1 is disengaged from its usual location at the nuclear pore complex (NPC) and sequestered in the nucleolus. PMID: 20647537
5. missegregation of a fluorescently tagged 2 microm circle reporter plasmid in a subset of ulp1 mutant cells suggest that Smt3 modification plays a role in both plasmid copy number control and segregation PMID: 15870298
6. Nucleoporins are required for maintenance of proper Ulp1 levels at nuclear pore complexes and for the establishment of the appropriate sumoylation of several cellular proteins. PMID: 17538013

Show More

Hide All

KEGG: sce:YPL020C

STRING: 4932.YPL020C