ULP2 Antibody

Code CSB-PA334734XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ULP2 Polyclonal antibody
Uniprot No.
Target Names
ULP2
Alternative Names
ULP2 antibody; SMT4 antibody; YIL031WUbiquitin-like-specific protease 2 antibody; EC 3.4.22.- antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ULP2 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Insertion mutation in SMT4 confers temperature and benomyl sensitivity; high copy suppressor of a temperature sensitive mutation in MIF2.
Gene References into Functions
  1. Ulp2 promotes rDNA silencing by opposing STUbL-mediated degradation of silencing proteins PMID: 28487408
  2. Extra copies of ChrI and ChrXII appear quickly following loss of active Ulp2 and can be eliminated following reintroduction of ULP2, suggesting that aneuploidy is a reversible adaptive mechanism to counteract loss of the SUMO protease PMID: 27585592
  3. mis-regulation is accompanied by a severe, recombination-dependent, block to chromosome segregation, revealing a critical role for Ulp2p in allowing sister chromatids to disjoin following HR DNA repair. PMID: 21483811
  4. Data show that the SUMO protease Ulp2 is required for resumption of cell division following DNA damage-induced arrest in Saccharomyces cerevisiae, although it is not required for DNA double-strand break repair. PMID: 17664284
  5. This review shows how Ulp2 protein enables the successful completion of mitosis following DNA damage. PMID: 18196960
  6. The N-terminal domains is essential for Ulp2 function and is required for nuclear targeting. PMID: 19225149
  7. C-terminal region of Ulp2 is phosphorylated during mitosis in a Cdc5-dependent manner. PMID: 19823017

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Protein Families
Peptidase C48 family
Database Links

KEGG: sce:YIL031W

STRING: 4932.YIL031W

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