unc-104 Antibody

1. Synaptic vesicle bound small GTPase ARL-8 activates UNC-104 by unlocking the autoinhibition. The results demonstrate that the autoinhibitory mechanism is utilized to regulate the distribution of transport cargoes and is important for synaptogenesis in vivo. PMID: 27524618
2. LIN-2 and SYD-2 both positively affect the velocity of UNC-104 PMID: 27172328
3. findings indicate that autophagy is spatially regulated in neurons through the transport of ATG-9 by KIF1A/UNC-104 to regulate neurodevelopment PMID: 27396362
4. Reduced function of UNC-104 accelerates motor circuit dysfunction with age, whereas upregulation of UNC-104 significantly improves motor function at advanced ages and also mildly extends lifespan. In addition, UNC-104-overexpressing animals outperform wild-type controls in associative learning and memory tests. PMID: 26877087
5. This study establishes an essential role of the CC1-FHA dimer for KIF1A/unc-104-mediated neuronal transport. PMID: 23669038
6. Protein with Tau-Like repeats (PTL)-1 affects retrograde axonal transport of uncoordinated (UNC)-104 protein in Caenorhabditis elegans. PMID: 21569846
7. putative UNC-104 interactors, namely UNC-16(JIP3), DNC-1(DCTN1/Glued) and SYD-2(Liprin-alpha), inherit different functions in steering UNC-104 to specific sub-cellular locations in the neuron PMID: 21195138
8. UNC-104 may get degraded at synapses upon release of cargo. PMID: 21079789
9. Unc104 neck regulates motility by switching from a self-folded, repressed state to a dimerized conformation that can support fast processive movement. PMID: 14638858
10. kinesin UNC-104 (KIF1A) is the microtubule motor specifically responsible for anterograde axonal transport of dense core vesicles at velocities of 1.6 microm/s-2.7 microm/s PMID: 15180830
11. An analysis was made of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by Map2. PMID: 17326138
12. UNC-104 forms SYD-2-dependent axonal clusters (appearing during the transition from L2 to L3 larval stages), which behave in FRAP experiments as dynamic aggregates. PMID: 19880746

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KEGG: cel:CELE_C52E12.2

STRING: 6239.C52E12.2b