UNC93B1 Antibody

1. Expression of a constitutively active STIM1 mutant, which no longer binds UNC93B1, restores antigen degradation and cross-presentation in 3d-mutated dendritic cells. PMID: 29158474
2. IgM(+)IgD(+)CD27(+) but not switched B cells were strongly reduced in MYD88-, IRAK-4-, and TIRAP-deficient patients, but not UNC-93B-deficient patients. PMID: 23002119
3. TLR3 is the important regulator of UNC93B1 that in turn governs the responsiveness of all TLR3 as the important regulator of UNC93B1 that in turn governs the responsiveness of all NAS Toll-like receptors PMID: 23166319
4. UNC93B1 expression is required for TLR3 cleavage and signaling. PMID: 22611194
5. UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling PMID: 22164301
6. To date only 2 children with UNC-93B deficiencies have been identified after isolated HSV-1 encephalitis. PMID: 21173679
7. Haplotype H3 of the hUNC-93B1 gene seems related to E/A-ratio in elderly men. The relationship between the hUNC-93B1 gene and the age at onset of heart failure and mortality support a view of a clinically relevant impact of the gene. PMID: 16111919
8. findings elucidate a genetic etiology for herpes simplex virus encephalitis in two children with autosomal recessive deficiency in the intracellular protein UNC-93B, resulting in impaired cellular interferon-alpha/beta and -lambda antiviral responses PMID: 16973841
9. study confirms the function of UNC-93B for innate immunity in human beings, and extends the knowledge for this molecule to the analysis of its regulation and the subcellular localization of the endogenous protein PMID: 18082565
10. No UNC-93B1 mutations were foundin patients with MRS. PMID: 18241724
11. IRAK-4-, MyD88-, and UNC-93B-deficient patients did not display autoreactive antibodies in their serum or develop autoimmune diseases, suggesting that IRAK-4, MyD88, and UNC-93B pathway blockade may thwart autoimmunity in humans. PMID: 19006693
12. regulates ligand-induced trafficking of TLR7 and TLR9 from the ER to endolysosomes, potential therapeutic target for controlling dysregulated TLR7/9 responses in autoimmune diseases PMID: 19120473
13. Individuals with congenital mutations develop severe HSV-1 encephalitis PMID: 19120481

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HGNC: 13481

OMIM: 608204

KEGG: hsa:81622

STRING: 9606.ENSP00000227471

UniGene: Hs.502989