unc-13 Antibody

1. C1-C2B exerts a basal inhibition on Munc13 in the primed state, permitting calcium- and lipid-dependent control of C1-C2B to modulate synaptic strength PMID: 28772122
2. Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder PMID: 28192369
3. results suggest that UNC-13L, UNC-13S, and Tomosyn form a molecular code that dictates the timing of neurotransmitter release PMID: 23951547
4. data reveal multiple roles of UNC-13 C2A domain, and suggest that spontaneous release and the fast phase of evoked release may involve a common pool of SVs at the active zone PMID: 24220508
5. The regulation of aging by unc-13 and sbt-1 is temperature-dependent. And the alterations in reproduction capability and stress response may be associated with the formation of this temperature-dependent property PMID: 19927169
6. UNC-13 may regulate multiple steps of the synaptic-vesicle cycle, and its interaction with syntaxin is required for synaptic transmission. PMID: 16271476
7. Even when inhibited synaptic vesicle priming is restored, synaptic transmission remains defective in unc-13 mutants, suggesting that UNC-13 is also required for other aspects of secretion. PMID: 16880125
8. This study investigates a role for UNC-13 in RNAi through analysis of RNAi penetrance in unc-13 and eri-1 mutant strains. UNC-13 functions in conjunction with ERI-1 in RNAi. PMID: 17276405
9. Calcium activated protein for secretion (CAPS)/UNC-31 and UNC-13 serve parallel and dedicated roles in dense-core vesicle and synaptic vesicle exocytosis, respectively, in the C. elegans nervous system. PMID: 17553987
10. Results support a model for docking in which UNC-13 converts syntaxin from the closed to the open state, and open syntaxin acts directly in docking vesicles to the plasma membrane. PMID: 17645391

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STRING: 6239.ZK524.2d

UniGene: Cel.16847