unc-3 Antibody

Code CSB-PA842372XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans unc-3 Polyclonal antibody
Uniprot No.
Target Names
unc-3
Alternative Names
unc-3 antibody; Y16B4A.1 antibody; Transcription factor unc-3 antibody; Uncoordinated protein 3 antibody; CEO/E antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans unc-3 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
May play a role in the expression of proteins essential for axonal pathfinding and/or neuronal differentiation in both sensory and motor neurons. Cooperates with jmjd-3.1 and wdr-5.1 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development.
Gene References into Functions
  1. Unc-3 is required for synaptogenesis.Synaptic input and output properties are temporally coordinated by Unc-3. PMID: 25913400
  2. in addition to playing a role in neuronal terminal differentiation, UNC-3 is a cell lineage-specific regulator of apoptosis. PMID: 25790851
  3. UNC-3 is a terminal selector for cholinergic motor neuron differentiation whose function is conserved across phylogeny. PMID: 22119902
  4. UNC-3 is a critical component of the transcription factor code that integrates cell-intrinsic developmental programs with external signals to specify sensory neuronal identity PMID: 16143323
  5. unc-3 represses a VC-like motor neuron program in the VA and VB motor neurons, which in wild-type animals control backwards and forwards locomotion, respectively. PMID: 18817768

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Subcellular Location
Nucleus.
Protein Families
COE family
Database Links
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