unc-36 Antibody

Code CSB-PA333888XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans unc-36 Polyclonal antibody
Uniprot No.
Target Names
unc-36
Alternative Names
unc-36 antibody; unc-72 antibody; C50C3.9/C50C3.10/C50C3.11 antibody; Voltage-dependent calcium channel unc-36 antibody; Pharyngeal calcium channel subunit alpha-2 antibody; Uncoordinated protein 36 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans unc-36 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
May act as an auxiliary subunit of the unc-2 voltage-gated calcium channel which appears to trigger calcium-activated signaling pathways that control the serotonin response. Inhibiting serotonin sensitivity of the vulval muscles results in egg laying defects. May act in both neurons and muscle cells to enhance motor activity as it is required for coordinated movement. Has a role in neural depolarization-induced calcium influx and pharyngeal pumping. Involved in restricting the expression of the putative olfactory receptor str-2 to only one of the two AWC neurons.
Gene References into Functions
  1. identified UNC-2/UNC-36 voltage-gated calcium channels and UNC-43/CaMKII as regulators of C. elegans synaptogenesis PMID: 23663262
  2. central role for EGL-19 and UNC-36 in excitability and functional activity of the mechanosensory neurons PMID: 16838374
Subcellular Location
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Decendants of the cells AB and AB.p (that give rise to nearly all non-pharyngeal neurons), decendants of P1 (that give rise to body muscle) and cell lineages that give rise to the adult and juvenile motor neurons. Expressed in body wall, vulval muscle and
Database Links

STRING: 6239.C50C3.9a.2

UniGene: Cel.16901

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