unc-37 Antibody

Code CSB-PA522334XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans unc-37 Polyclonal antibody
Uniprot No.
Target Names
unc-37
Alternative Names
unc-37 antibody; esg antibody; W02D3.9 antibody; Transcription factor unc-37 antibody; Uncoordinated protein 37 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans unc-37 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity. May function with transcription factor mls-1 to promote uterine muscle specification and formation.
Gene References into Functions
  1. TBX-2 functions as an UNC-37 dependent transcriptional repressor PMID: 27265867
  2. MLS-1 specifies uterine muscle fate by repressing target gene expression, and this function depends on interaction with UNC-37 PMID: 21852953
  3. Besides their phenotypic similarities, unc-37 and lsy-22 show genetic interactions and UNC-37 and LSY-22 proteins also physically bind to each other in vivo. PMID: 20431118
  4. ceh-30 defines a checkpoint that integrates the sex determination signal TRA-1 and the cell fate determination and survival signal UNC-86 to control the sex-specific activation of the apoptosis program in sensory neurons through UNC-37. PMID: 18056429
Subcellular Location
Nucleus.
Protein Families
WD repeat Groucho/TLE family
Database Links

KEGG: cel:CELE_W02D3.9

STRING: 6239.W02D3.9.2

UniGene: Cel.7359

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