Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans unc-6 Polyclonal antibody

Uniprot No.

P34710

Target Names

unc-6

Alternative Names

unc-6 antibody; F41C6.1Netrin unc-6 antibody; Uncoordinated protein 6 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans unc-6 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. In particular, it is required for the guidance of axons from neurons, including SubL neurons and AIY interneurons, into the nerve ring. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in dendritic morphogenesis; may act by association with unc-40 at the tips of growing dendrites for interaction with unc-5 on the apposing branch to induce mutual repulsion. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation of synapses between the AVA interneurons and the PHB sensory neurons.

Gene References into Functions

rom these studies we conclude that FMO-1, FMO-4, FMO-5, and EHBP-1 represent new players downstream of UNC-6/Netrin receptors and Rac GTPases that inhibit growth cone filopodial protrusion in repulsive axon guidance PMID: 28859089
LON-2/glypican acts as a modulator of UNC-40/DCC-mediated guidance to fine-tune axonal responses to UNC-6/netrin signals during migration. PMID: 26148345
Ire-1/xbp-1 pathway of the unfolded protein response is crucial for establishing positional information of UNC-6/Netrin. PMID: 25469499
UNC-116/KHC acts in part with the cell and axon migration molecules UNC-6/Netrin and UNC-40/DCC in this process, but in parallel to SAX-3/Robo. PMID: 23475988
This study demonistrated that Netrin (UNC-6) mediates dendritic self-avoidance PMID: 22426253
We found that the guidance cue UNC-6 (Netrin) is required for both axon and dendrite development. PMID: 21186357
Mutants with impaired growth cone functions, such as unc-6, often exhibit abnormal terminations and inappropriate trajectories at the distal ends of the M2 axons. PMID: 12885562
loss-of-function mutations in clr-1 enhance netrin-dependent axon attraction PMID: 15232111
Data show that UNC-6 and UNC-40 function during axon formation to initiate, maintain and orient asymmetric neuronal growth. PMID: 16520734
Genetic analyses indicate that MIG-10/RIAM/lamellipodin, a cytoplasmic adaptor protein, functions downstream of the attractive guidance cue UNC-6/netrin to direct the ventral migration of the AVM and PVM axons in C. elegans. PMID: 16563765
UNC-6 expressed by the VPC and the VNC cooperatively regulates the complex HSN axon guidance. PMID: 17320069
study show that connectivity between two interneurons, AIY and RIA, in Caenorhabditis elegans is orchestrated by a pair of glial cells that express UNC-6 (netrin) PMID: 17916735
Together, these results characterize an invasive membrane domain in vivo, and reveal a role for UNC-6 (netrin) in polarizing this domain towards its basement membrane target. PMID: 19098902

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Subcellular Location

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Epidermal basal lamina.

Database Links

KEGG: cel:CELE_F41C6.1

STRING: 6239.F41C6.1.2

UniGene: Cel.6945

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unc-6 Antibody

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