unc-62 Antibody

Code CSB-PA865060XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans unc-62 Polyclonal antibody
Uniprot No.
Target Names
unc-62
Alternative Names
unc-62 antibody; T28F12.2 antibody; Homeobox protein unc-62 antibody; Uncoordinated protein 62 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans unc-62 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Acts redundantly with ceh-20 and ceh-40 to perform overlapping roles during embryogenesis. Required for postembryonic development of the ectoderm, including the Q, V and P cell lineages, playing a crucial role in ensuring that these cells and their descendants undergo their invariant patterns of cell division, migration, fusion and morphogenesis. Has a role in the mig-13 pathway to promote anterior migration of neuroblasts in the Q lineage. Required for multiple roles in regulating vulva development. Associates with homeobox ceh-60 to regulate gene expression, including repression of genes involved in innate immunity and activation of genes involved in vitellogenesis. Involved in lipid homeostasis, contributing to the formation of the cuticle.
Gene References into Functions
  1. Different Meis/UNC-62 isoforms act through specific regions of the unc-55 promoter. UNC-62 isoforms differentially regulate the mRNA and protein expression of UNC-55. PMID: 27634571
  2. These results illustrate how unc-62 regulation of intestinal gene expression is responsible for limiting lifespan during the normal aging process. PMID: 23468654
  3. UNC-62 plays essential roles in regulating cell fate specification & differentiation in the mesodermal M lineage. UNC-62 functions together with CEH-20 in regulating these processes. PMID: 19643105
Subcellular Location
Nucleus.
Protein Families
TALE/MEIS homeobox family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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