unc-7 Antibody

Code CSB-PA312700XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans unc-7 Polyclonal antibody
Uniprot No.
Target Names
unc-7
Alternative Names
unc-7; unc-12; unc-124; R07D5.1; Innexin unc-7; Uncoordinated protein 7
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans unc-7 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Structural component of the gap junctions. Required for coordinated locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. Plays a role in regulating male mating behavior by positively regulating inhibitory neuronal signaling transduction between chemosensory and mechanosensory neurons, and thus ensuring spicule insertion attempts are confined to the hermaphrodite vulva during copulation.
Gene References into Functions
  1. This study showed that isoform, which perturbs DOP-2 signaling in the PCB neuron and its electrical partner, hook neurons. PMID: 26156999
  2. UNC-7 is localized perisynaptically throughout development and is required in presynaptic neurons to regulate active zone differentiation. PMID: 19386917
Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein Families
Pannexin family
Tissue Specificity
In hermaphrodites, expressed in all premotor and motor neurons, and in tail neurons. In males, expressed in the anal depressor, gubernacular erector, gubernacular retractor and anterior oblique muscles, SPC, PCA, PCB, HOA, ray, head ganglion and ventral c
Database Links

STRING: 6239.R07D5.1a

UniGene: Cel.17909

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