unc-8 Antibody

Code CSB-PA630358XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans unc-8 Polyclonal antibody
Uniprot No.
Target Names
unc-8
Alternative Names
unc-8 antibody; R13A1.4Degenerin unc-8 antibody; Uncoordinated protein 8 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans unc-8 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Gene References into Functions
  1. The authors propose that the depolarizing effect of UNC-8-dependent sodium import elevates intracellular calcium in a positive feedback loop involving the voltage-gated calcium channel UNC-2 and the calcium-activated phosphatase TAX-6/calcineurin to initiate a caspase-dependent mechanism that disassembles the presynaptic apparatus. PMID: 27403890
  2. Neurotoxic UNC-8(G387E) and UNC-8(A586T)mutants encode hyperactivated channels blocked by extracellular calcium and magnesium. PMID: 23898007
Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
Amiloride-sensitive sodium channel (TC 1.A.6) family
Database Links

STRING: 6239.R13A1.4

UniGene: Cel.12253

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