ureI Antibody

Code CSB-PA600591XA01HUV
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Product Details

Full Product Name
Rabbit anti-Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) ureI Polyclonal antibody
Uniprot No.
Target Names
ureI
Alternative Names
ureI antibody; HP_0071 antibody; Acid-activated urea channel antibody; Urease accessory protein UreI antibody
Raised in
Rabbit
Species Reactivity
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Immunogen
Recombinant Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) ureI protein
Immunogen Species
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Functions as a specific, H(+)-activated urea channel that increases the rate of urea entry into the cytoplasm, resulting in activation of cytoplasmic urease at acidic medium pH. Is essential for H.pylori gastric survival and colonization. Is necessary for the adaptation of urease activity to the extracellular pH, as in the presence of urea, UreI rapidly enhances the production of ammonia in the extracellular medium when the pH of the medium was decreased to pH5 or below.
Gene References into Functions
  1. The extent of binding of urea by HpUreI was increased at lower pH. PMID: 21877689
  2. Assembly of a pH-regulatory complex of active urease with UreI provides an advantage for periplasmic buffering. PMID: 19854893
Subcellular Location
Cell inner membrane; Multi-pass membrane protein.
Protein Families
AmiS/UreI family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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