vav-1 Antibody

Code CSB-PA677182XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans vav-1 Polyclonal antibody
Uniprot No.
Target Names
vav-1
Alternative Names
vav-1 antibody; C35B8.2Protein vav-1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans vav-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Acts as guanine nucleotide exchange factor (GEF) for Rho GTPase. Has a critical roles in the generation of rhythmic behaviors: feeding, defecation and ovulation by dynamically regulating the concentration of intracellular calcium. Plays a role in male tail tip morphogenesis.
Gene References into Functions
  1. We show that Rho/Rac-family GTPases and the signaling molecule inositol triphosphate (IP(3)) act downstream of VAV-1 signaling and that the VAV-1 pathway modulates rhythmic behaviors by regulating the concentration of intracellular Ca(2+).(VAV-1) PMID: 16213217
  2. VAV-1 in the ALA interneuron also serves a critical function to suppress locomotion and feeding behavior during sleep-like quiescence PMID: 26801183
  3. The data describe a novel neuromodulatory role for VAV-1-dependent signaling in the regulation of motor circuit activity and locomotion. PMID: 25412913
Tissue Specificity
Strong expression in the pharynx, proximal gonad, spermatheca, intestine and rectal epithelia.
Database Links

KEGG: cel:CELE_C35B8.2

STRING: 6239.C35B8.2b

UniGene: Cel.7082

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