Product Details

Full Product Name

Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) kdrl Polyclonal antibody

Uniprot No.

Q8AXB3

Target Names

kdrl

Alternative Names

kdrl antibody; flk antibody; flk-1 antibody; flk1 antibody; flka antibody; kdr antibody; kdra antibody; vegfr2 antibody; vegfr4 antibody; vegr2 antibody; si:ch211-276g21.4 antibody; Vascular endothelial growth factor receptor kdr-like antibody; EC 2.7.10.1 antibody; Fetal liver kinase 1 antibody; FLK-1 antibody; Kinase insert domain receptor-A antibody; Kinase insert domain receptor-like antibody; Protein-tyrosine kinase receptor flk-1 antibody; Vascular endothelial growth factor receptor 4 antibody; VEGFR-4 antibody

Raised in

Rabbit

Species Reactivity

Danio rerio (Zebrafish) (Brachydanio rerio)

Immunogen

Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) kdrl protein

Immunogen Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis.

Gene References into Functions

Ca(2+) oscillations depended upon VEGF receptor-2 (Vegfr2) and Vegfr3 in endothelial cells budding from the dorsal aorta (DA) and posterior cardinal vein, respectively. PMID: 26588168
methylation of Lys(1041) promotes the activation of VEGFR-2 and that similar posttranslational modification could also regulate the activity of other receptor tyrosine kinases. PMID: 24300896
Data indicate that the increase in FLT1/sFLT1 protein levels upon miR-10 knockdown inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 signaling: [miR10] PMID: 22955733
Early Flk1 expression may be induced by cooperative interactions between Gata, Tcf/Lef, Cdx and ER71/Etv2 under the control of Bmp, Wnt and Fgf signaling. PMID: 22071109
Data show that flk1 is not required for proper vasculogenesis and hematopoiesis in zebrafish embryos; however, the disruption of flk1 impairs the formation or function of vessels generated by sprouting angiogenesis PMID: 12194822
ISKNV ORF48R can stimulate expression of flk1; knockdown of FLK-1 results in the disappearance of pericardial edema and dilation at the tail region of zebrafish embryos induced by overexpression of ISKNV ORF48R in early stages of embryonic development. PMID: 18305039
It was propose to rename flk1/kdra gene kdr-like. PMID: 18516225

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Families

Protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily

Tissue Specificity

First expressed in embryos between 5- and 7-somites. At 7 somites, expressed in discrete bilateral stripes both anteriorly and posteriorly, and in a transverse ectodermal stripe in the hindbrain. From 7-somites, expression seems to extend caudally from th

Database Links

KEGG: dre:796537

STRING: 7955.ENSDARP00000007209

UniGene: Dr.75094

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kdrl Antibody

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