vif Antibody

Code CSB-PA163925XA01SHF
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Product Details

Full Product Name
Rabbit anti-Simian immunodeficiency virus agm.grivet (isolate AGM gr-1) (SIV-agm.gri) (Simian immunodeficiency virus African green monkey grivet) vif Polyclonal antibody
Uniprot No.
Target Names
vif
Alternative Names
vif antibody; Virion infectivity factor antibody; Vif antibody; Q protein antibody; SOR protein antibody
Raised in
Rabbit
Species Reactivity
Simian immunodeficiency virus agm.grivet (isolate AGM gr-1) (SIV-agm.gri) (Simian immunodeficiency virus African green monkey grivet)
Immunogen
Recombinant Simian immunodeficiency virus agm.grivet (isolate AGM gr-1) (SIV-agm.gri) (Simian immunodeficiency virus African green monkey grivet) vif protein
Immunogen Species
Simian immunodeficiency virus agm.grivet (isolate AGM gr-1) (SIV-agm.gri) (Simian immunodeficiency virus African green monkey grivet)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Counteracts the innate antiviral activity of APOBEC3G. Forms a complex with host APOBEC3G thus preventing the entry of this lethally hypermutating enzyme into progeny virions. Functions as an adapter molecule, recruiting APOBEC3G to the ubiquitin-proteasome machinery. Targets APOBEC3G for degradation through the assembly with elongin BC complex, CUL5 and RBX1. Binds viral RNA and affects the stability of viral nucleoprotein core. May play a role in viral morphology.
Gene References into Functions
  1. Data indicate that SIVmac239 Vif protein efficiently degrades human DNA cytosine deaminase APOBEC3B protein (huA3B). PMID: 26544511
  2. The arginine at position 14 of the SIV Vif is a critical residue for virus restriction by rhA3D, rhA3G and rhA3H. PMID: 24418547
  3. simian immunodeficiency virus (SIV) Vif binds to and requires CBF-beta to degrade rhesus macaque APOBEC3G PMID: 22190037
  4. Efficient splicing of SIV vif mRNA is tightly controlled and requires the SA1 site. PMID: 15950999
  5. Results describe a novel vif-sensitive antiviral activity of human cyclophilin A that may limit zoonotic transmission of SIV and the first demonstration of CypA encapsidation into a virus other than human immunodeficiency virus type 1. PMID: 17522232

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Subcellular Location
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion.
Protein Families
Primate lentivirus group Vif protein family
Database Links

KEGG: vg:1490005

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