vif Antibody

Code CSB-PA516625XA01HXD
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Product Details

Full Product Name
Rabbit anti-Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1) vif Polyclonal antibody
Uniprot No.
Target Names
vif
Alternative Names
vif antibody; Virion infectivity factor antibody; Vif antibody; SOR protein) [Cleaved into: p17; p7] antibody
Raised in
Rabbit
Species Reactivity
Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1)
Immunogen
Recombinant Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1) vif protein
Immunogen Species
Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G. Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions. Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F. In turn, they are directed to the 26S proteasome for degradation. Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism. May interact directly with APOBEC3G mRNA in order to inhibit its translation. Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core. Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells.
Subcellular Location
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion.
Protein Families
Primate lentivirus group Vif protein family
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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