VPS13 Antibody

1. findings support a model in which Mcp1 and Vps13 work as functional effectors of vacuole-mitochondria contact sites, while tethering is mediated by other factors, including Vps39. PMID: 28864540
2. his study demonstrates that VPS13 is also important for mitochondrial integrity. Introduction of VPS13A mutations identified in chorea acanthocytosis patients at cognate sites in yeast VPS13 are specifically defective in compensating for the lack of ERMES, suggesting that mitochondrial dysfunction might be the basis for chorea acanthocytosis. PMID: 27280386
3. The Vps13p-Cdc31p complex is directly required for transgolgi network late endosome transport and TGN homotypic fusion. PMID: 28122955
4. These results suggest that PI3P regulates the functioning of Vps13, both in protein trafficking and actin cytoskeleton organization. Attenuation of PI3P-binding ability in the mutant hVps13A protein may be one of the reasons for its mislocalization and disrupted function in cells of patients suffering from chorea-acanthocytosis . PMID: 28334785
5. Vps13 dynamically localizes to vacuole-mitochondria and to vacuole-nucleus contact sites depending on growth conditions, suggesting that ERMES function can be bypassed by the activity of other contact sites. PMID: 26370498
6. VPS13 is important for formation of the prospore membrane. PMID: 22442115

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KEGG: sce:YLL040C

STRING: 4932.YLL040C