VPS21 Antibody

1. Data indicate that efficient Vps21 recycling requires both Ypt7 and endosome-vacuole fusion, thus suggesting extended control of a GAP cascade beyond Rab interactions. PMID: 25971802
2. Endosomal class E compartments accumulate chronically active Vps21, the yeast Rab5A ortholog. PMID: 22899724
3. CORVET (class C core vacuole/endosome tethering) binds to SNAREs and Rab5/Vps21-GTP and can specifically tether Vps21-positive membranes. PMID: 23417307
4. Gyp3 spatially restricts active Vps21 to intermediate endosomes. PMID: 22748138
5. Msb3 forms a specific transition complex with Vps21 and has the highest activity of all recombinant GAPs for Vps21 PMID: 22593206
6. regulation of PI(3)P synthesis by Rab5 and Vps21 is essential for TORC1 function in both contexts. PMID: 22547071
7. Data show that that Vps21, a Saccharomyces cerevisiae ortholog of mammalian endosomal Rab5, functions in trans with itself and with at least two other endosomal Rabs to directly mediate GTP-dependent tethering. PMID: 22157956
8. Vps8 interacts and cooperates with the activated Rab5 homolog Vps21 to induce the clustering of late endosomal membranes. PMID: 19828734
9. Transport among Golgi, endosome, and vacuole is controlled by two homologous tethering complexes, the previously identified HOPS complex at the vacuole and a novel endosomal tethering (CORVET) complex, which interacts with the Rab GTPase Vps21. PMID: 17488625

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KEGG: sce:YOR089C

STRING: 4932.YOR089C