VPS4 Antibody

Datasheet

Code	CSB-PA159736XA01CZD
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) VPS4 Polyclonal antibody

Uniprot No.

Q5AG40

Target Names

VPS4

Alternative Names

VPS4 antibody; CAALFM_C503090WA antibody; CaO19.11814 antibody; CaO19.4339 antibody; Vacuolar protein sorting-associated protein 4 antibody

Raised in

Rabbit

Species Reactivity

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Immunogen

Recombinant Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) VPS4 protein

Immunogen Species

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Pre-vacuolar protein sorting protein involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex. Required for extracellular secretion of the secreted aspartyl proteases SAP2, SAP4, SAP5, and SAP6. Its regulation of the pre-vacuolar secretory pathway is critical for virulence.

Gene References into Functions

These data suggest deletion of Vps4 decreases overall hyphal growth at pH 7 and increases the growth of multiple hyphae induced by serum, which indicates that the ESCRTs may make a Rim101-independent contribution to hyphal growth. PMID: 26700222
results suggest VPS4 contributes to several key aspects of oral epithelial but not uroepithelial infection, and plays no major role in the pathogenesis of Candida vaginitis; VPS4 contributes to virulence according to the specific tissue that is infected PMID: 25483774
lack of VPS4 results in a decrease of canonically secreted proteins whilst having a limited effect on non-canonically secreted extracellular proteins. PMID: 19819358
VPS4 is required for extracellular secretion of Sap4-6p PMID: 18814053

Subcellular Location

Endosome membrane; Peripheral membrane protein.

Protein Families

AAA ATPase family

Database Links

KEGG: cal:CAALFM_C503090WA

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

What Should You Know about Exosomes? Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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