VTS1 Antibody

1. The work couples transcriptome-wide measurements of binding affinity, sequence, and structural determinants of binding, and phenotypic outcomes to provide a comprehensive portrait of Vts1 function. Notably, the impact of Vts1 on transcript abundance was largely independent of where it bound within an mRNA, challenging prevailing assumptions about how this RBP drives RNA degradation. PMID: 28325876
2. VTS1 gene modulates nonsense suppression and vegetative growth in S. cerevisiae PMID: 22215010
3. VTS1 is a multi-copy suppressor of dna2-K1080E, a lethal mutant allele of DNA2 that lacks DNA helicase activity. PMID: 20007605
4. Results describe the 1.6 Angstroms X-ray crystal structure of the Vts1 SAM domain in its unliganded state, and the NMR solution structure of this domain in its RNA-bound state. PMID: 16375924
5. These results provide a structural basis for the versatility of the Vts1 SAM domain in protein and RNA-recognition. PMID: 16405996
6. 2.0-A X-ray structure of the Vts1p SAM domain bound to a high-affinity RNA ligand PMID: 16429151
7. present the NMR structures of the Vts1p-Smaug recognition element (SRE) complex and the free SRE PMID: 16429155
8. identified several genes in S. cerevisiae that seem to be regulated by Vts1p and contain one or more copies of the Smaug response element PMID: 16429156

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KEGG: sce:YOR359W

STRING: 4932.YOR359W