Name: wapl Antibody
Brand: CUSABIO
SKU: CSB-PA894314XA01DLU

Product Details

Full Product Name	Rabbit anti-Drosophila melanogaster (Fruit fly) wapl Polyclonal antibody
Uniprot No.	Q9W517
Target Names	wapl
Alternative Names	wapl antibody; pasc antibody; CG3707Protein wings apart-like antibody; Protein parallel sister chromatids antibody
Raised in	Rabbit
Species Reactivity	Drosophila melanogaster (Fruit fly)
Immunogen	Recombinant Drosophila melanogaster (Fruit fly) wapl protein
Immunogen Species	Drosophila melanogaster (Fruit fly)
Conjugate	Non-conjugated
Clonality	Polyclonal
Isotype	IgG
Purification Method	Protein A/G
Concentration	It differs from different batches. Please contact us to confirm it.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form	Liquid
Tested Applications	ELISA, WB (ensure identification of antigen)
Protocols	ELISA Protocol
Troubleshooting and FAQs	Antibody FAQs
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables	① 200ug * antigen (positive control); ② 1ml * Pre-immune serum (negative control);
Quality Guarantee	① Antibody purity can be guaranteed above 90% by SDS-PAGE detection; ② ELISA titer can be guaranteed 1: 64,000; ③ WB validation with antigen can be guaranteed positive;
Lead Time	Made-to-order (14-16 weeks)

Target Background

Function (From Uniprot)	Has a role in female meiotic chromosome segregation in females; proximal heterochromatin is involved in chromosome pairing during female meiosis. Is a dominant suppressor of both white and Stubble position-effect variegation (PEV), while it is a weak enhancer of brown variegation.
Gene References into Functions	findings suggests that the mutant Wapl-AG might exert its effects through changes in cohesin binding; Wapl-AG was found to increase the stability of cohesin binding to polytene chromosomes PMID: 23034634 Study shows that DNA replication and cohesin acetylation promote binding of Sororin to cohesin, and that Sororin displaces Wapl from its binding partner Pds5; in the absence of Wapl, Sororin becomes dispensable for cohesion. PMID: 21111234 Nipped-B, Pds5, and the Wapl protein that interacts with Pds5 all play unique roles in cohesin chromosome binding. PMID: 20696838
Protein Families	WAPL family
Database Links	KEGG: dme:Dmel_CG3707 STRING: 7227.FBpp0070413

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wapl Antibody

Code	CSB-PA894314XA01DLU
Size	Enquire
Have Questions?	Leave a Message or Start an on-line Chat