wts-1 Antibody

Code CSB-PA825824XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans wts-1 Polyclonal antibody
Uniprot No.
Target Names
wts-1
Alternative Names
wts-1 antibody; T20F10.1Serine/threonine-protein kinase WARTS homolog antibody; EC 2.7.11.1 antibody; LATS kinase homolog antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans wts-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Phosphorylates yap-1 which may negatively regulate yap-1 nuclear localization. Plays an essential role in larval development. Regulates growth, the formation of gut granules, lifespan and cell and body sizes probably in synergy with the TGF-beta sma/mab pathway. Does not appear to regulate apoptosis and proliferation. In addition, may synergize with the TGF-beta daf-7 dauer pathway to regulate entry into the dauer stage. Maintains the cellular integrity of intestinal cells by regulating the localization of apical actin and junctional proteins.
Gene References into Functions
  1. Data suggest that WTS-1 kinase plays important roles in the integrity of the apical membrane structure of intestinal cells. PMID: 19605499
  2. Genetic analyses show that Ce-wts-1 functions synergistically with the TGF-beta Sma/Mab pathway to regulate body length. PMID: 19737560
Subcellular Location
Cytoplasm. Apical cell membrane.
Protein Families
Protein kinase superfamily, AGC Ser/Thr protein kinase family
Tissue Specificity
Expressed in muscles and epithelial tissues including pharynx, intestine and hypodermis. Expressed in vulval and spermathecal seam cells.
Database Links

KEGG: cel:CELE_T20F10.1

STRING: 6239.T20F10.1

UniGene: Cel.5279

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