WLS Antibody

Datasheet
Code CSB-PA459670XA01DMJ
Product Type Polyclonal Antibody
Uniprot No. B4QPR1
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Drosophila simulans (Fruit fly) WLS protein
Raised in Rabbit
Species Reactivity Drosophila simulans (Fruit fly)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugate
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Protein wntless wls GD12816
Immunogen Species Drosophila simulans (Fruit fly)
Gene Names wls
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exosome-like vesicles. Postsynaptic wls is required for the trafficking of fz2 through the fz2-interacting protein Grip (By similarity).
Subcellular Location Cell junction, synapse, presynaptic cell membrane, Multi-pass membrane protein, Cell junction, synapse, postsynaptic cell membrane, Multi-pass membrane protein, Cell membrane, Multi-pass membrane protein, Endoplasmic reticulum membrane, Multi-pass membrane protein, Endosome membrane, Multi-pass membrane protein, Golgi apparatus membrane, Multi-pass membrane protein
Protein Families Wntless family
Database Links

KEGG: dsi:Dsimw501_GD12816

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