RAT1 Antibody

1. Data indicate that Rat1 exonuclease (Rat1) acts catalytically in 5.8S and 25S rRNA processing but binds to the pre-rRNA prior to these activities. PMID: 24498264
2. Degradation of the nascent transcript allows Rat1 to pursue Pol II in a guided fashion and arrive at the site of RNA exit from Pol II. PMID: 23689372
3. Rat1 exonuclease pre-rRNA folding and 5.8S rRNA maturation are regulated by a cluster of ribosome synthesis factors PMID: 21811236
4. data suggest that Rat1p serves to terminate RNAPII molecules engaged in the production of uncapped RNA, regardless of their position on the gene locus. PMID: 20188675
5. Rat1 5' --> 3' exonuclease are localized at 3' ends of protein coding genes; in rat1-1 Delta cells, RNA 3' to polyadenylation sites is greatly stabilized and termination defects are seen at many genes PMID: 15565157
6. results suggest a unified allosteric/torpedo model in which Rat1 is not a dedicated termination factor, but is an integrated component of the cleavage/polyadenylation apparatus PMID: 16598041
7. the activity of Rat1 is also required for efficient termination by RNA polymerase I (Pol I) on the rDNA PMID: 18413717

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KEGG: sce:YOR048C

STRING: 4932.YOR048C