rp2 Antibody

Code CSB-PA980507XA01DIL
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Product Details

Full Product Name
Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) rp2 Polyclonal antibody
Uniprot No.
Target Names
rp2
Alternative Names
rp2 antibody; Protein XRP2 antibody
Raised in
Rabbit
Species Reactivity
Danio rerio (Zebrafish) (Brachydanio rerio)
Immunogen
Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) rp2 protein
Immunogen Species
Danio rerio (Zebrafish) (Brachydanio rerio)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. In the retina, required for maintenance of rod and cone photoreceptor cells. May have a role in normal retinal localization of the transducins GNB1 and GNAT1, and the rhodopsin kinase GRK1.
Gene References into Functions
  1. study also reveals a role of the C-terminal domain of RP2 in maintaining the overall protein stability. PMID: 28209709
  2. maternal rp2 mRNA is essential for successful embryonic development and thus contributes to egg developmental competence PMID: 26134862
  3. Knockout of RP2 decreases GRK1 and rod transducin subunits and leads to photoreceptor degeneration in zebrafish PMID: 26034134
  4. Results suggest that RP2 plays a key role in photoreceptor development and maintenance in zebrafish PMID: 21738648
  5. Zebrafish RP2 is widely expressed throughout development. ZFRP2 knockdown caused retinal degeneration in zebrafish. PMID: 21282572

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Subcellular Location
Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, cilium.
Protein Families
TBCC family
Tissue Specificity
In the retina, detected in both rod and cone photoreceptors (at protein level). Has strongest expression in the retinal outer nuclear layer (ONL) and weaker expression in the outer plexiform layer (OPL) and inner plexiform layer (IPL) (at protein level).
Database Links
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Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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