ARR1 Antibody

Code CSB-PA578389XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ARR1 Polyclonal antibody
Uniprot No.
Target Names
ARR1
Alternative Names
ARR1 antibody; ACR1 antibody; YAP8 antibody; YPR199C antibody; P9677.15 antibody; AP-1-like transcription factor YAP8 antibody; Arsenic compound resistance protein 1 antibody; Arsenical-resistance protein ARR1 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ARR1 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Transcription activator required for resistance to arsenic compounds and for a regulated expression of ACR2, ACR3 and YCF1.
Gene References into Functions
  1. As(III) binding to Yap8 acts as a molecular switch that converts inactive Yap8 into an active transcriptional regulator. PMID: 26711267
  2. Leu26 is required for Yap8 binding to DNA and that this residue together with Asn31, hinder Yap1 response element recognition by Yap8, thus narrowing its DNA-binding specificity. PMID: 24358276
  3. ARR1 is degraded by the ubiquitin-proteasome pathway in untreated cells, whereas arsenite-exposure results in its stabilization and gene activation. PMID: 17200139
  4. Yap8p requires distinct DNA-binding motifs to induce gene expression and propose that this fact contributed towards a separation of function between AP-1 proteins during evolution PMID: 18593383
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
BZIP family, YAP subfamily
Database Links

KEGG: sce:YPR199C

STRING: 4932.YPR199C

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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