hecw-1 Antibody

Code CSB-PA270896XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans hecw-1 Polyclonal antibody
Uniprot No.
Target Names
hecw-1
Alternative Names
hecw-1 antibody; F45H7.6 antibody; E3 ubiquitin-protein ligase hecw-1 antibody; EC 2.3.2.26 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans hecw-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
E3 ubiquitin-protein ligase. Functions in the OLL neurons in the anterior ganglion to inhibit avoidance to microbial pathogens such as P.aeruginosa although worms do display avoidance behavior, vacating a P.aeruginosa lawn within 24 hours. Likely to act by inhibiting the neuropeptide receptor npr-1.
Gene References into Functions
  1. HECW-1 functions in a pair of sensory neurons to inhibit P. aeruginosa lawn avoidance behaviour through inhibition of the neuropeptide receptor NPR-1 PMID: 22089131
Subcellular Location
Cytoplasm.
Tissue Specificity
Expressed in the nervous system throughout the body. In the anterior ganglion, expression is limited to the two lateral outer labial neurons OLLL and OLLR.
Database Links

KEGG: cel:CELE_F45H7.6

UniGene: Cel.10460

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