ZC3HAV1 Antibody

1. results indicate that low ZAP expression is common in hepatocellular carcinoma (HCC), is correlated with the progression of HCC and with a poorer prognosis for HCC patients, and plays an important role in HCC carcinogenesis PMID: 30196292
2. In response to DNA damage, activated and auto-poly-ADP-ribosylated PARP1 dissociates from HSF1-PARP13, and redistributes to DNA lesions and DNA damage-inducible gene loci. PMID: 29158484
3. The results indicate that an equilibrium between ZAP and enterovirus 3C protease controls viral infection. PMID: 29182509
4. Herpes simplex virus 1 UL41 was shown for the first time to evade the antiviral function of human ZAP via its RNase activity. PMID: 26625984
5. The association of the ZAP ribonucleoprotein particle with many interferon-stimulated gene products indicates it may be a key player in the interferon response. PMID: 26001115
6. Suppressing Matrin 3 powers a heightened and broader ZAP restriction of HIV-1 gene expression. PMID: 26129669
7. PARP13 regulates RNA in stress and disease. [review] PMID: 25851173
8. PARP13 regulates cellular mRNA post-transcriptionally and functions as a pro-apoptotic factor by destabilizing TRAILR4 transcript. PMID: 25382312
9. results show that PARP13 lacks the structural requirements for ADP-ribosyltransferase activity PMID: 25635049
10. Contrary to previous assumptions, these results indicate an essential function of the PARP-like domain in hZAP-L's antiviral activity. PMID: 24457973
11. Data suggest that two isoforms of ZAP (ZAP-long and -short) inhibit replication of hepatitis B virus and replication of viral DNA in hepatocytes through posttranscriptional down-regulation of viral RNA. PMID: 23853601
12. S-farnesylation is crucial for targeting the long-isoform of ZAP to endolysosomes and enhancing the antiviral activity of this immune effector. PMID: 23776219
13. ZAP inhibits M2 expression and regulates the maintenance of MHV-68 latency PMID: 22951821
14. The Thr851Ile SNP of ZC3HAV1 is significantly associated with susceptibility to multiple sclerosis PMID: 22319148
15. Results indicate that ZAP inhibits HIV-1 by recruiting both the 5' and 3' mRNA degradation machinery to specifically promote the degradation of multiply spliced HIV-1 mRNAs. PMID: 21876179
16. shorter isoform (ZAPS)stimulates interferon responses mediated by the RNA helicase RIG-I PMID: 21102435
17. ZAP is a direct target gene of IRF3 action in cellular antiviral respon PMID: 20048147
18. These findings suggest that ZAP recruits the cellular RNA degradation machinery for the degradation of viral RNA. PMID: 20451500
19. Our findings demonstrate that ZAP can synergize with another IFN-induced factor(s) for maximal alphaviruses antiviral activity and that ZAP's intrinsic antiviral activity on virion production and cell survival can have cell-type-specific outcomes. PMID: 17928353
20. This study finds that human ZAP encodes a potent antiviral activity against alphaviruses. PMID: 18225958
21. ZAP, TIPARP and FLJ22693 proteins with TPH, WW and PARP-like domains constitute the TIPARP family. PMID: 12851707

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HGNC: 23721

OMIM: 607312

KEGG: hsa:56829

STRING: 9606.ENSP00000242351

UniGene: Hs.133512