Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ZIM17 Polyclonal antibody

Uniprot No.

P42844

Target Names

ZIM17

Alternative Names

ZIM17 antibody; FMP28 antibody; HEP1 antibody; TIM15 antibody; YNL310C antibody; N0381 antibody; Mitochondrial protein import protein ZIM17 antibody; Mitochondrial import inner membrane translocase subunit TIM15 antibody; mtHsp70 escort protein 1 antibody; mtHsp70-associated motor and chaperone protein TIM15/ZIM17 antibody; MMC antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ZIM17 protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Involved in protein import into mitochondria. Acts as a Hsp70-specific chaperone that prevents self-aggregation of the matrix Hsp70 chaperones SSC1 (mtHSP70) and SSQ1, thereby maintaining their function in mitochondrial protein import and Fe/S protein biosynthesis. May act together with PAM18 as co-chaperone to facilitate recognition and folding of imported proteins by SSC1 in the mitochondrial matrix.

Gene References into Functions

Zn(2+) induced TIM15 folding is essential for its function and likely occurs in mitochondrial matrix where high concentrations of Zn(2+) were reported. PMID: 23063975
Arabidopsis Zinc Ribbon 3 is the ortholog of yeast mitochondrial HSP70 escort protein HEP1 and belongs to an ancient protein family in mitochondria and plastids. PMID: 22841711
Human DNLZ partially complements the growth of Deltazim17 Saccharomyces cerevisiae. PMID: 22162012
Cells lacking Zim17 (Tim15/Hep1), have limited respiration activity, mimic the metabolic response to iron starvation and suffer a dramatic increase in nuclear genome recombination. PMID: 21511814
example of a "fractured" J-protein, where a protein like Zim17 contributes a zinc finger domain to Type III J-proteins PMID: 15383543
Tim15/Zim17 cooperates with mtHsp70 to facilitate import of presequence-containing proteins into the matrix. PMID: 15642367
findings suggest that Zim17 plays a specific role in preventing protein aggregation in the mitochondrial matrix, and that aggregation of Hsp70s causes pleiotropic effects on protein biogenesis and mitochondrial morphology PMID: 15992824

Hide All

Subcellular Location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Soluble matrix protein loosely associated with the inner membrane.

Database Links

KEGG: sce:YNL310C

STRING: 4932.YNL310C

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

Code	CSB-PA337237XA01SVG
Size	Enquire
Have Questions?	Leave a Message or Start an on-line Chat

ZIM17 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background