bsk Antibody

1. Increased expression of the Drosophila JNK basket in the setting of reduced cindr expression was found to result in even more severe apoptosis, whilst ectopic death was found to be reduced if retinas were heterozygous for basket. PMID: 29133184
2. n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing PMID: 28231245
3. Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction. PMID: 26387958
4. This study demonstrated that the mechanism by which Bsk is required for pruning is through reducing the membrane levels of the adhesion molecule Fasciclin II (FasII) PMID: 26586184
5. Study solves the crystal structure of unphosphorylated DJNK in complex with adenylyl imidodiphosphate (AMP-PNP) and magnesium. PMID: 26377800
6. In a genetic screen, we identified signaling by the EGFR pathway as important for apoptosis-induced proliferation acting downstream of JNK signaling PMID: 24497843
7. We propose that JNK is a central stress response effector that is activated by nucleolar stress in Drosophila larvae PMID: 23412656
8. dUev1a modulates TNF-JNK mediated tumor progression and cell death in Drosophila. PMID: 23726905
9. Raw negatively regulates JNK signaling during gonad morphogenesis, and increased JNK signaling is sufficient to cause ensheathment defects. PMID: 22575490
10. ectopic Dpp led to DJNK-dependent cardial apoptosis through the non-canonical TGF-beta pathway during late embryogenesis of Drosophila. PMID: 22114909
11. stress-induced apoptosis in Drosophila is dependant on an amplification loop mediated by dp53 and JNK PMID: 21886179
12. Pan-neuronal knockdown of JNK mRNA expression by RNA interference resulted in a decrease in both sleep and longevity. PMID: 22197814
13. Data show that regeneration of genetically ablated tissue requires JNK activity, and that the JNK pathway is activated at the leading edges of healing tissue and not in apoptotic cells, and is required for regulation of healing and regenerative growth. PMID: 20215351
14. These findings demonstrate that Eiger can initiate cell death through an IAP-sensitive cell death pathway via JNK signaling. PMID: 12065414
15. Results introduce the Jun N-terminal kinase (JNK) signaling pathway as a genetic determinant of aging in Drosophila melanogaster. PMID: 14602080
16. Relish limits the duration of JNK activation in response to Gram-negative infections. Degradation of TAK1 leads to a rapid termination of JNK signaling, resulting in a transient JNK-dependent response that precedes sustained induction of immune loci. PMID: 15037551
17. The convergence of JNK signaling and IIS on Foxo provides a model to explain the effects of stress and nutrition on longevity. PMID: 15820683
18. JNK acts as the downstream mediator of the LKB1-dependent apoptosis. PMID: 16273080
19. Study found that the left-right asymmetric cell rearrangement in the circular visceral muscle was regulated by D-JNK signaling and required for the LR asymmetric looping of the anterior-midgut. PMID: 17915206
20. regulators of JNK were identified; using genetic & phosphoproteomics data, an integrative network algorithm to construct a JNK phosphorylation network was implemented PMID: 18927396
21. influences regeneration in the gut by directing proliferation of intestinal stem cells, contributes to the loss of tissue homeostasis in old and stressed intestines PMID: 18940735
22. JNK activity upregulates genes involved in intracellular transport in order to provide an increased level of trafficking activity in cells undergoing complex morphogenetic arrangements such as dorsal closure. PMID: 19427848

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KEGG: dme:Dmel_CG5680

STRING: 7227.FBpp0079676

UniGene: Dm.1448