Human C1q/TNF-related protein-3,Cartonectin/CTRP3/CORS-26 ELISA Kit

Instructions
Code CSB-E13426h
Size 96T,5×96T,10×96T
Trial Size 24T ELISA kits trial application
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Product Details

Target Name C1q and tumor necrosis factor related protein 3
Alternative Names C1ATNF3 ELISA Kit; C1q and tumor necrosis factor related protein 3 ELISA Kit; C1QT3_HUMAN ELISA Kit; C1qtnf3 ELISA Kit; Cartonectin ELISA Kit; Collagenous repeat containing sequence of 26 kDa ELISA Kit; collagenous repeat-containing sequence 26 kDa protein ELISA Kit; Complement C1q tumor necrosis factor related protein 3 ELISA Kit; Complement C1q tumor necrosis factor-related protein 3 ELISA Kit; Corcs ELISA Kit; CORS 26 ELISA Kit; Cors ELISA Kit; CORS26 ELISA Kit; CTRP3 ELISA Kit; FLJ37576 ELISA Kit; OTTHUMP00000115918 ELISA Kit; OTTHUMP00000219981 ELISA Kit; PRO1484 ELISA Kit; Secretory protein CORS26 ELISA Kit; UNQ753 ELISA Kit
Abbreviation C1QTNF3
Uniprot No. Q9BXJ4
Species Homo sapiens (Human)
Sample Types serum, plasma, cell culture supernates
Detection Range 0.156 ng/mL-10 ng/mL
Sensitivity 0.039 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Others
Assay Principle quantitative
Measurement Sandwich
Precision
Intra-assay Precision (Precision within an assay): CV%<8%      
Three samples of known concentration were tested twenty times on one plate to assess.  
Inter-assay Precision (Precision between assays): CV%<10%      
Three samples of known concentration were tested in twenty assays to assess.    
             
Linearity
To assess the linearity of the assay, samples were spiked with high concentrations of human CTRP3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
  Sample Serum(n=4)  
1:1 Average % 88  
Range % 81-95  
1:2 Average % 92  
Range % 90-102  
1:4 Average % 96  
Range % 91-100  
1:8 Average % 95  
Range % 89-102  
Recovery
The recovery of human CTRP3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
Sample Type Average % Recovery Range  
Serum (n=5) 93 85-100  
EDTA plasma (n=4) 101 90-110  
             
             
Typical Data
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
ng/ml OD1 OD2 Average Corrected  
10 1.839 1.952 1.896 1.741  
5 1.616 1.586 1.601 1.446  
2.5 1.354 1.271 1.313 1.158  
1.25 0.912 0.932 0.922 0.767  
0.625 0.617 0.609 0.613 0.458  
0.312 0.412 0.388 0.400 0.245  
0.156 0.263 0.251 0.257 0.102  
0 0.159 0.151 0.155    
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

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Target Background

Gene References into Functions
  1. we have developed a diagnostic and prognostic prediction model for Prostate cancer. C1QTNF3 was revealed as a promising biomarker for Prostate cancer PMID: 29861410
  2. CTRP3 may be a promising therapeutic target for the treatment of liver fibrosis. PMID: 28320106
  3. Elevated serum CTRP 3 levels were closely related to the prevalence and severity of coronary artery disease, suggesting that it might be regarded as a novel biomarker for CAD. PMID: 28754090
  4. defensive roles in suppressing inflammation and fibrosis in polymeric IgA complex-stimulated mesangial cells; may target the NF-kappaB and TGF-beta/Src-Smad3 signaling pathways to play multipotent roles in relieving the pathological progression of IgA nephropathy PMID: 27309491
  5. CTRP3 promotes mitochondrial biogenesis in cardiomyocytes via AMPK/PGC-1alpha pathway. PMID: 27793739
  6. Low CTRP3 expression is associated with diabetic retinopathy. PMID: 28632765
  7. decreased levels of CTRP3 and especially CTRP13 were associated with increased risk of T2DM and CAD PMID: 28033351
  8. both plasma CTRP-3 and HMGB-1 levels were significantly associated with pre-diabetes mellitus and newly diagnosed type 2 diabetes after adjusting for several confounders PMID: 27738641
  9. This research suggested that CTRP3 might protect chondrocytes against IL-1beta-induced osteoarthritis in a cell model by suppressing the FGFR1- Ras/PI3K/Akt signaling-mediated growth inhibitory pathway. PMID: 27930985
  10. CTRP3 could improve insulin sensitivity of insulin resistant 3T3-L1 adipocytes by decreasing inflammation and ameliorating insulin signalling transduction, indicating that CTRP3 may be a new target for the prevention and cure of insulin resistance and type 2 diabetes. PMID: 25185846
  11. CTRP3 is present in cord blood and might be involved in fetal growth PMID: 26656444
  12. CTRP3 overexpression altered chemokine levels and attenuated systemic inflammation in the setting of obesity. PMID: 26997632
  13. Lower Circulating C1q/TNF-Related Protein-3 (CTRP3) Levels Are Associated with Obesity PMID: 26222183
  14. plasma CTRP-3 is strongly associated with glucose and lipid metabolism, chronic inflammation, and insulin resistance. PMID: 26073386
  15. Results show that cartonectin may serve as a novel biomarker for the prediction and early diagnosis of type 2 diabetes mellitus patients. PMID: 25409499
  16. Patients with acute coronary syndrome or stable angina pectoris had significantly lower circulating CTRP-3 concentrations compared to controls. PMID: 24417980
  17. CTRP3 promotes vascular calcification by enhancing phosphate-induced osteogenic transition of VSMC through reactive oxygen species-extracellular signal-regulated kinase 1/2-Runx2 pathway. PMID: 24578384
  18. Data suggest that serum/omental adipose tissue (AT) cartonectin levels are lower in women with polycystic ovary syndrome; treatment with a hypoglycemic agent (metformin) increases serum cartonectin levels in these women and in omental AT explants. PMID: 24152681
  19. Data suggest that CTRP3 is expressed in subcutaneous and visceral adipocytes; CTRP3 appears to play important roles in adipocyte (epinephrine-induced) lipolysis, inflammation/infection, and adipokine/resistin secretion. PMID: 23174996
  20. Data suggest that patients exhibit significantly elevated circulating CTRP-3 in type 2 diabetes or prediabetes compared with subjects with normal glucose tolerance. Plasma CTRP-3 might be useful biomarker for atherosclerosis. PMID: 22837306
  21. This study provides the first functional evidence linking CTRP3 to hepatic glucose metabolism and establishes CTRP3 as a novel adipokine. PMID: 20952387
  22. CTRP-3 inhibits three basic and common proinflammatory pathways involved in obesity and type 2 diabetes mellitus (adipo-inflammation) by acting as an endogenous LPS antagonist of the adipose tissue. PMID: 20739398
  23. Genotyping of the shared variants in a Puerto Rican sample of 118 cases and 136 controls did not reveal either allelic or genotype association with schizophrenia. PMID: 20483475
  24. Blood level is determined by a glucose tolerance test in normal adults PMID: 17311679
  25. CTRP3/cartducin may be involved as a novel angiogenic factor in the formation of neointima following angioplasty. PMID: 17534697
  26. CORS26/cartonectin is a new adipokine that differentially regulates the secretion of classical adipokines, with marked differences between the human and the murine systems. PMID: 18421280

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Subcellular Location Secreted
Tissue Specificity Expressed in colon and small intestine.
Database Links

HGNC: 14326

OMIM: 612045

KEGG: hsa:114899

STRING: 9606.ENSP00000371497

UniGene: Hs.171929

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