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24T ELISA Kit Trial Size (Only USD$150/ kit)
The product CSB-E04679h is a sandwich ELISA kit developed to measure levels of human matrix metalloproteinase 7 (MMP7) in serum, plasma, or tissue homogenates. The enzyme-substrate chromogenic reaction is also used to amplify the signal and quantify the levels of the analyte through the intensity of the colored product. The color intensity positively correlates with the amount of MMP7 bound in the initial step.
MMP7 is a secreted protease that is expressed by glandular and mucosal epithelial cells, keratinocytes, fibroblasts, and macrophages and secretes zinc and calcium endopeptidases. Like other MMPs, MMP7 can act on the extracellular matrix and thereby regulate cell migration, bone growth, wound healing, remodeling, and tissue repair. Additionally, MMP7 plays an important role in the maintenance of innate immunity in organs such as the lungs and intestines where it proteolytically activates anti-bacterial peptides such as pro-defensins. MMP7 has been demonstrated to modulate the occurrence and development of cancers and mediate the proliferation, differentiation, metastasis, and invasion of several types of cancer cells via various mechanisms.
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