Human insulin-like growth factors binding protein 4,IGFBP-4 ELISA Kit

Code CSB-E04592h
Size 96T,5×96T,10×96T
Price Request a Quote or Start an on-line Chat
Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
* The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now

Product Details

Target Name
insulin-like growth factor binding protein 4
Alternative Names
AI875747 ELISA Kit; BP 4 ELISA Kit; BP4 ELISA Kit; Deb2 ELISA Kit; HT29 IGFBP ELISA Kit; IBP 4 ELISA Kit; IBP-4 ELISA Kit; IBP4 ELISA Kit; IBP4_HUMAN ELISA Kit; IGF binding protein 4 ELISA Kit; IGF-binding protein 4 ELISA Kit; IGF-BP4 ELISA Kit; IGFBP 4 ELISA Kit; IGFBP-4 ELISA Kit; IGFBP4 ELISA Kit; Insulin Like Growth Factor Binding Protein 4 ELISA Kit; Insulin-like growth factor-binding protein 4 ELISA Kit
Abbreviation
IGFBP4
Uniprot No.
Species
Homo sapiens (Human)
Sample Types
serum, plasma, tissue homogenates
Detection Range
62.5 ng/mL-4000 ng/mL
Sensitivity
15.6 ng/mL
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Signal Transduction
Assay Principle
quantitative
Measurement
Sandwich
Precision

Linearity

Recovery

Typical Data

Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx
Description

This Human IGFBP4 ELISA Kit was designed for the quantitative measurement of Human IGFBP4 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 62.5 ng/mL-4000 ng/mL and the sensitivity is 15.6 ng/mL.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
(From Uniprot)
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Gene References into Functions
  1. The authors also identified single-nucleotide polymorphisms in NRP2 and IGFBP4 loci that increase and reduce risk of lichen planus in hepatitis C virus-infected patients, respectively. PMID: 28065765
  2. the results of this study raise the possibility that human mesenchymal stem cells actions involve a negative-regulatory mechanism that suppresses Treg proliferation by releasing IGFBP-4 PMID: 28724578
  3. IGFBP-4 maybe act as a potential negative regulator in the progression of lung cancer through downregulation of COX-2. PMID: 28150906
  4. Patients with type 2 Diabetes Mellitus had lower serum concentrations of IGFBP-4 compared to controls. PMID: 28179448
  5. Data show that insulin-like growth factor binding protein-4 (IGFBP-4) was significantly elevated in lupus nephritis, particularly those with renal pathology chronicity changes. PMID: 27019456
  6. The present study provides the first evidence that apoptosis inhibitor of macrophages binds to IGFBP2, 3 and 4. PMID: 26135353
  7. Data show that co-transfection with cDNA encoding stanniocalcin-1 abrogates the proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A) toward IGF-binding protein 4 (IGFBP-4). PMID: 26195635
  8. PLasma IGFBP-4 levels are not acutely altered following myocardial infarction treated with heparin and percutaneous coronary intervention. PMID: 25489725
  9. High IGFBP-4 fragment levels were associated with increased all-cause and cardiovascular mortality rates in T1D patients with and without diabetic nephropathy. PMID: 26046968
  10. Data indicate co-localization of insulin-like growth factor binding proteins IGFBP-4, IGFBP-5 in the syncytiotrophoblast layer of first trimester placental villi as early as 5 weeks of gestational age. PMID: 25475528
  11. IGF-1/IGFbp4 signaling regulated the post-developmental adipose tissue expansion. PMID: 24778188
  12. Despite the relation of CT-IGFBP4 to a more severe coronary artery disease, CT- and NT-IGFBP4, in contrast to our report based on total PAPP-A, failed to predict any long-term outcomes in patients with stable cardiovascular disease. PMID: 24201068
  13. these findings demonstrate an oncogenic property for IBP in promoting the metastatic potential of breast cancer cells. PMID: 23975422
  14. PAPP-A and IGFBP-4 gene expression (microarray analysis) was significantly upregulated in IL-1beta- or TNF-alpha-exposed cells. PMID: 24060054
  15. IGFBP-4 modulates the efficiency of estrogen-triggered activation of the Akt/PKB signaling pathway which has been associated with growth factor/ ERalpha cross-talks. PMID: 23499909
  16. Epigenetic silencing of UCHL1 and IGFBP4 in giant cell tumors may be important for malignant transformation of the cells PMID: 23603559
  17. IGFBP-4 was by far the most predominant IGFBP by immunoassay PMID: 23079385
  18. role of IGFBP-4 in regulating IGF bioavailability and provide new clues for the prevention and treatment of FGR (Fetal growth restriction). PMID: 22689691
  19. IGF1 haplotypes are associated with genetic susceptibility to high myopia in Chinese adults, whereas IGFBP3 and IGFBP4 are unlikely to be important in the genetic predisposition to high myopia PMID: 22332214
  20. The resistance of VEGF-stimulated angiogenesis to IGFBP-4 inhibition appears to depend on sustained activation of p38 MAPK as blocking its activity restored the anti-angiogenic effects of IGFBP-4 on VEGF-induced blood vessel growth in vivo PMID: 22134921
  21. This study demonistrated that IGFBP4 was significantly decreased in skeletal muscel in patient with amyotrophic lateral sclerosis. PMID: 22246875
  22. circulating IGFBP-4 levels are not influenced by secondary hyperparathyroidism in vitamin D deficiency rickets PMID: 21274331
  23. This is a first report documenting that IGFBP-4 expression in RCC activates cell growth, metastasis, Wnt/beta-catenin signaling and may be involved in RCC metastasis. PMID: 21207373
  24. These findings suggest that the expression of IGFBP-4 in adenocarcinoma cells in vivo is downregulated by epigenetic silencing in association with tumor differentiation, resulting in disruption of the mechanism of IGFBP-4-mediated growth inhibition. PMID: 21166939
  25. enterocyte HT-29 cell differentiation correlates with an increase in IGFBP-4 levels PMID: 12163000
  26. results are the first evidence of IGF-independent IGFBP-4 actions on granulosa cell steroidogenesis PMID: 12193384
  27. role in sequestration of insulin-like growth factor-1 and consequent impairment of insulin-like growth factor-1 action in skeletal tissue PMID: 12733722
  28. A novel SP3 binding site was identified in the promoter of IGFBP4. PMID: 14767471
  29. IGFBP-4 proteolysis and local regulation of IGF availability may be altered in malignant ovarian epithelial cells PMID: 15146551
  30. Data suggested that growth factor- and cytokine-mediated changes in IGFBP abundance regulate postnatal fibroblast cell. proliferation PMID: 15204833
  31. IGFBP-4 is a novel dB-cAMP-induced anti-angiogenic and anti-tumorigenic mediator that may be a promising candidate for glioblastoma therapy. PMID: 16586492
  32. Overexpression of IGFBP-4 in vivo has been reported to decrease the growth of prostate cancer and altered expression of IGFBP-4 in vivo in colon and other cancers needs to be explored as locally available IGFs appear to stimulate mitogenesis. (review) PMID: 16685432
  33. local increased collagen synthesis was preceded by an elevation of local concentration of IGFBP-4, suggesting that IGFBP-4 may have a key role in the IGF-axis effect on the human collagen synthesis in vivo PMID: 16973813
  34. the IGF system may have a limited role in the pathogenesis of GCT with PAPP-A subserving a function other than IGFBP-4 proteolysis PMID: 17177834
  35. Ratios between IGFBPs and IGF (insulin-like growth factors), different IGFBPs, sequential proteolytic cleavage of IGFBPs, and association of activating proteinases are key elements in the regulation of IGF receptor stimulation. PMID: 17312271
  36. IGFBP-4 may have a role in increasing necrosis and apoptosis, but in decreasing mitosis PMID: 17824980
  37. conclusion: decreased IGFBP-4 tumor expression might be a step in the progression from primary to metastatic melanoma; data lend support to a recently-described novel tumor suppressor role of secreting IGFBPs in melanoma PMID: 19025658
  38. IGFBP4, which can inhibit IGF action, also increased during in-vitro decidualization of cultured human ESCs. PMID: 19038974

Show More

Hide All

Subcellular Location
Secreted.
Database Links

HGNC: 5473

OMIM: 146733

KEGG: hsa:3487

STRING: 9606.ENSP00000269593

UniGene: Hs.462998

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X