Function
(From Uniprot)
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.
Gene References into Functions
- Syp can be quantified on circulating tumor cells and that Syp expression correlates with resistance to abiraterone and enzalutamide in castration resistant prostate cancer. PMID: 29289429
- Report of a novel SYP mutation identified in a patient with a severe neurodevelopmental disorder. Mutation does not impact on synaptic vesicles endocytosis or trafficking of common cargoes. However it is unable to support sybII retrieval in synaptophysin knockout neurons. It fully restores plasma membrane levels of sybII, suggesting that activity-dependent trafficking of sybII is specifically affected by this mutation. PMID: 28887151
- The expression of MAP2 and SYP proved most relevant to neurocognitive functioning in HIV-infected patients. PMID: 26637429
- Synaptophysin-positive epithelial proliferations suggest breast neoplasms. PMID: 28630050
- Suggest that INSM1 is valuable for identification of the high-grade thoracic neuroendocrine carcinomas that are sometimes negative for synaptophysin, chromogranin, and CD56. PMID: 28719469
- High synaptophysin expression is associated with neuroendocrine differentiation in colorectal cancer. PMID: 28351413
- Study reveals the presence of two selected neuronal markers, MAP-2 and SYP mRNAs and protein expression, in eutopic endometrium and in endometriotic lesions. PMID: 26604067
- Anomalous expression of all intermediate filament proteins and synaptophysin was found in significant subsets of malignant melanoma. PMID: 26022451
- Docosahexaenoic acid-containing phosphatidylcholines and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease. PMID: 25410733
- This study demonstrated that synaptophysin was significantly lower in Down syndrome with Alzheimer disease compared with Down syndrome alone and similar to sporadic Alzheimer disease. PMID: 24927707
- The results of this study suggested that SYP may be primarily associated with ADHD-I and its genetic mechanism may be gender-specific. PMID: 23726717
- The paucity or absence of synaptophysin-positive cells in all three phenotypes of Barrett's mucosa might mirror a sequela of chronic inflammation caused by the particular pathogenic bacteria present in the immediate oesophageal microenvironment. PMID: 23763443
- Data suggest that multi-antibody assay of TTF1, Vimentin, p63 CD56, chromogranin and synaptophysin may be of special value, especially in diagnosing small biopsies. PMID: 23418554
- the author showed that, in cutaneous basal cell carcinoma, the expression of NCAM and c-KIT was high, PDGFRA was intermediate, and chromogranin A and synaptophysin was relatively low PMID: 23292839
- Depressed patients showed significant decreases in synaptophysin (SYN) and VGLUT1 expression. PMID: 23022470
- Lower levels of synaptophysin were found in the visual cortex of dementia with Lewy bodies patients compared to controls. PMID: 23242284
- Normal goblet cells found in duodenal adenomas express synaptophysin. PMID: 22843923
- The data of this study suggested that the common polymorphisms of the SYP gene appear not to play a major role in conferring susceptibility to schizophrenia. PMID: 22348818
- This is the first report of immunoreactivity for inhibin-alpha and synaptophysin in synovial sarcoma PMID: 22055401
- NCAM1, SYPT and CGA expressions are differently regulated by neuroendocrine phenotype-specific transcription factors in lung cancer cells. PMID: 22449227
- Finding that synaptophysin is produced by Paneth cells adds new information which might help to unravel the riddle of the ultimate biological significance of these puzzling cells. PMID: 22210727
- The expression of synaptophysin and GAD67 was downregulated in the basolateral nucleus of schizophrenics. PMID: 22099865
- Prescence of of APOEepsilon4 allele and MAPT H2 haplotype in frontotemporal lobar degeneration had a significant influence on the expression of synaptophysin and SNAP-25 PMID: 21073671
- Significant decreases in synaptophysin levels are observed in hippocampal neurons from Alzheimer's disease patients. PMID: 20847448
- during prenatal development synaptophysin expression increased gradually in the red nucleus PMID: 12077483
- we have identified a functional binding site for REST in the first intron of the human synaptophysin gene indicating that REST blocks human synaptophysin gene transcription through an intronic neuron-specific silencer element. PMID: 12492469
- AP180 had an overall expression similar to synaptophysin, the immunoreactivity for the two proteins did not always co-localize. PMID: 12493563
- This protein was found in cells of adrenal cortical neoplasms. PMID: 12575533
- expression and localization of chromogranin A (CgA), chromogranin B (CgB), synaptophysin, and insulin were ultrastructurally studied with the immunogold technique in porcine and human pancreatic islet neuroendocrine cells PMID: 12826904
- Synaptophysin immunoreactivity was significantly reduced in both the inner and outer molecular layers of the dentate gyrus (both p<0.01 by paired t-test), but not in the hilus. In contrast to patients with schizophrenia. PMID: 15694236
- Synaptophysin was absent near neurons bearing clusters of oligomer Abeta, suggesting that accumulated oligomer Abeta, but not fibrillar Abeta, is closely associated with synaptic failure, a major cause of cognitive dysfunction. PMID: 16721760
- Results describe patterns of synaptophysin protein and mRNA expression in the human hippocampal formation from birth to old age. PMID: 16807900
- Synaptophysin regulates micro-opioid receptor trafficking and signaling. PMID: 17005904
- Overexpression of Synaptophysin is associated with squamous carcinoma and adenocarcinoma of the lung PMID: 17724707
- synaptophysin levels slowly increased from birth until age 5 and then increased more rapidly to peak in late childhood around age 10 then decrease until the adult level was reached by age 16 PMID: 17916412
- Synaptophysin(SYN) was correlated with mini-mental status examination scores. Frontal cortex SYN protein levels may protect neuronal function in oldest-old individuals and reflect compensatory responses that may be involved with maintaining cognition. PMID: 18006193
- Chromogranin A-, serotonin-, synaptophysin- and vascular endothelial growth factor-positive endocrine cells and the prognosis of colorectal cancer: an immunohistochemical and ultrastructural study. PMID: 18771509
- Additional immunohistochemical detection of neuroendocrine differentiation (chromogranin-A, synaptophysin, and neural-cell adhesion molecule) in non-small cell lung cancer is presently not of prognostic importance. PMID: 19652998
- Chromogranin A, synaptophysin and CK 20 were not expressed in any basal cell carcinoma PMID: 19724850
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Involvement in disease
Mental retardation, X-linked 96 (MRX96)
Subcellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.
Protein Families
Synaptophysin/synaptobrevin family
Tissue Specificity
Expressed in the brain, with expression in the hippocampus, the neuropil in the dentate gyrus, where expression is higher in the outer half of the molecular layer than in the inner half, and in the neuropil of CA4 and CA3.
