Gene References into Functions |
- Based on our results, we conclude that SDC1 on DC negatively regulates DC migration. PMID: 28453867
- findings support a key role for Sdc1 in modulating pulmonary protection by FFP after hemorrhagic shock. PMID: 28107214
- 2-O-sulfated domains in syndecan-1 heparan sulfate halt disease progression and promote liver repair by enhancing hepatocyte survival in acetaminophen-induced liver injury PMID: 28543100
- CD138 expression on fully mature Antibody secreting cells (ASCs) provides a selective survival advantage over less mature, newly minted ASCs, by enhancing pro-survival cytokine signaling. PMID: 28381397
- Sdc1 deficiency results in increased susceptibility to colitis-associated tumorigenesis. PMID: 28350804
- MMP7 shedding of syndecan-1/CXCL1 complexes functions as a checkpoint that restricts neutrophil activation at sites of epithelial injury. PMID: 26934670
- Data show that heparanase-1 (HPA-1) induced shedding of heparan sulfate chain from syndecan-1 (SDC-1) facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1/VEGF-C complex into the medium of hepatocarcinoma cell. PMID: 28209511
- This study indicates that, while syndecan-1 is important for providing a barrier to acute S. aureus infection in PD, it does not affect peritoneal fibrosis and angiogenesis. PMID: 26832929
- Data suggest a potential mechanism of diabetic enteropathy, which is depending remarkably on syndecan-1 (Sdc1) and -beta-D-glucuronidase heparanase (HPSE). PMID: 25702768
- Study showed the expression, distribution and function of syndecan-1 in primary sensory neurons after nerve injury PMID: 26002314
- A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung metastasis formation. PMID: 25912030
- The PPARgamma agonist rosiglitazone rescues Sdc1-/- intradermal adipose tissue, placing PPARgamma downstream of Sdc1 in triggering adipocyte differentiation PMID: 25101993
- no expression within the vasculature PMID: 25972509
- Specific structural motifs in syndecan-1 HS promote Staphylococcus aureus corneal infection by inhibiting neutrophil CRAMP. PMID: 25931123
- These results demonstrate that defective motility in Sdc-1(-/-) macrophages promotes a persistent inflammatory state with relevance to the pathogenesis of atherosclerosis. PMID: 25550207
- Sdc1 affects arteriogenesis in response to hindlimb ischemia and is required in the local tissue environment for normal arteriogenesis. PMID: 25194470
- Syndecan-1 promotes vascular smooth muscle cell differentiation and quiescence. PMID: 24587062
- The conserved domain 2 (C2) and variable (V) regions of syndecan- 1 cytoplasmic tail mediate heparanase processing. PMID: 24788042
- These data show that CD138(+) cells, induced by treatment with CS, migrate into the bone marrow and may displace other antigen-specific plasma cells. PMID: 24555985
- studies support a key role for sdc-1 in endothelial mechanosensing and regulation of endothelial phenotype. PMID: 24554698
- In Sdc-1(-/-) mice, early leukocyte recruitment via the choroid plexus is enhanced, and IL-6 is elevated, which collectively results in higher numbers of the disease inducing Th17 cells in the CNS, thereby contributing to enhanced disease severity. PMID: 24078687
- high expression of the ppGalNAc-T13 gene generates tTn antigen on Syndecan 1, leading to enhanced invasion and metastasis via the formation of a complex consisting of integrin alpha5beta1, Syndecan 1, and MMP-9 in the glycolipid-enriched microdomain/rafts. PMID: 23814067
- Syndecan-1 does not appear to be a prerequisite for the existence of an endothelial glycocalyx. PMID: 23428342
- early differentiated CD138(high)MHCII(+) rather than terminally differentiated CD138(high)MHCII(low) plasma cells may be involved in the renal inflammatory injury in lupus, due to CXCR3 expression and IgG secretion. PMID: 23520491
- Clearance of triglyceride-rich lipoproteins by hepatic SDC1 is atheroprotective and mediated by multivalent binding to ApoE and ApoAV. PMID: 23676495
- These results suggest that insulin stimulates the association of insulin receptor with syndecan-1 and the complex formation of syndecan-1 and integrin could play an important role in ERK I/II-ALP signaling pathway in osteoblast cells. PMID: 23252577
- Sdc1 in the germinal niche is a key HSPG regulating the maintenance and proliferation of NPCs during cortical neurogenesis, in part by modulating the ability of NPCs to respond to Wnt ligands. PMID: 22936997
- The loss of syndecan-1 expression in the epithelial cell membrane is associated with tumor cell growth and invasiveness PMID: 22686587
- These results suggest that syndecan-1 may have a crucial role in the survival of injured motor neurons and in nerve regeneration after injury. PMID: 22944346
- Data suggest a mechanism for the inhibitory effects of Sdc-1 on cell growth that involves the interaction between the cytoplasmic domain of Sdc-1 and the SUMO-1 E3 ligase, Topors. PMID: 22912899
- did not see a significant reduction in reporter-gene transduction by papillomaviruses in syndecan-1 null mice PMID: 22995187
- the lung epithelium requires the syndecan-1 transmembrane domain to govern cell migration and is independent from its ability to control cell adhesion via the extracellular domain. PMID: 22936802
- The 1.5-kb upstream region of the syndecan-1 gene was sufficient to induce its expression in dental papilla, and binding of Sp3 transcription factor may play a pivotal role in this syndecan-1 induction. PMID: 22134060
- Reduced Syndecan-1 is associated with severe colitis in IL-10 knockout mice. PMID: 21987406
- These results suggest that syndecan 1 plays a novel role in the protective effects of enteral glutamine in the postischemic gut. PMID: 22706022
- Data show that wildtype-syndecan-1(WT-sdc1) and unshedding-syndecan-1(uS-sdc1) are successfully constructed. PMID: 22482411
- syndecan-1 promotes tubular survival and repair in ischemia/reperfusion injury PMID: 22237752
- The myocardial levels of expression of Sdc1 mRNA and protein increased significantly in myocardial infarction(MI); The expression of soluble Sdc1 in the sera of the rats in the MI group followed a similar pattern PMID: 21842422
- Heparan sulfate chains of syndecan-1 regulate ectodomain shedding. PMID: 22298773
- Molecular functions of syndecan-1 in disease.(review) PMID: 22033227
- Bacillus anthracis infection contribute to the formation of thrombi consisting of aggregated bacteria, vWF, shed SDC-1, fibrin, activated platelets and fibronectin. PMID: 22001909
- Syndecan-1 displays a protective role in aortic aneurysm formation by modulating T cell-mediated responses. PMID: 22173227
- Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype PMID: 21757697
- SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis PMID: 21257720
- Sdc1 shedding is activated in colitis. Heparin, which mimics Sdc1 functions, relieves colitis severity by inhibiting Sdc1 shedding and downregulating cytokines expression. PMID: 20936359
- previously unknown bacterial subversion mechanism where S. aureus exploits the capacity of syndecan-1 ectodomains to inhibit neutrophil-mediated bacterial killing mechanisms in an heparan sulfate-dependent manner to promote its pathogenesis in the cornea PMID: 21127056
- the loss of syndecan1 (sdc1) in corneal stromal cells (CSC) impacts cell migration rates, the sizes and composition of focal and fibrillar adhesions, the activation of integrins, and the assembly of fibronectin into fibrils PMID: 20580707
- Zoledronic acid can inhibit the growth of KM3 cells in a dose-dependent manner and inhibit CD138 expression. PMID: 19642368
- Sdc1 has a protective effect during experimental colitis. PMID: 20008145
- MMP7 shedding of syndecan-1 facilitates wound closure by causing the alpha(2)beta(1) integrin to assume a less active conformation thereby removing restrictions to migration PMID: 19668337
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