Mouse Thymic stromal lymphopoietin(TSLP) ELISA kit

1. this paper shows that IL-33 promotes gastrointestinal allergy in a TSLP-independent manner PMID: 28656964
2. a new pathway for the activation of Treg involving in tumor-derived HMGB1 and TSLP, and have important implications for incorporating HMGB1 inhibitors into cancer immunotherapy. PMID: 29116372
3. Effects of Linalyl Acetate on Thymic Stromal Lymphopoietin Production in Mast Cells. PMID: 30011850
4. findings suggest a role of TSLP in directly promoting Th2 cell effector function and support the notion of TSLP as a key driver of Th2 PMID: 29339496
5. Thymic stromal lymphopoietin and IL-33 promote skin inflammation and vaccinia virus replication in a mouse model of atopic dermatitis. PMID: 26830114
6. the pathological mechanisms of particulate matter PM2.5 may be associated with allergic/steroidresistant airway inflammation, Tcell helper (Th)1/Th2 cytokine production and upregulation of TSLP expression in a murine model of allergic and steroid-resistant asthma. PMID: 28765890
7. Results suggest combinatorial mechanisms involved in the tissue-selective regulation of thymic stromal lymphopoietin (TSLP) transcription in epidermal keratinocytes and intestinal epithelial cell(s) (IEC). PMID: 28115699
8. these results suggest that TSLP-TSLPR signaling is pivotal in the induction of nasal respiratory immunity against pathogenic pneumococcal infection PMID: 27924821
9. blockading the JAK/STAT pathway restrains inflammatory Th2 cell response induced by TSLP-DCs in allergic rhinitis. PMID: 28214951
10. study concludes that IL-33 and TSLP are required for epithelial cell IL-25 expression, mucous metaplasia, and ILC2 expansion following early-life rhinovirus infection PMID: 28701507
11. TSLP plays a role in dysfunction of airway epithelial adherens junctions E-cadherin in house dust mite (HDM)-induced asthma. Mice treated with an anti-TSLP mAb ameliorated airway inflammation, the decreasing and aberrant distribution of E-cadherin and beta-catenin as well as phosphorylation(p)-AKT induced by HDM. In vitro, HDM increased the expression of TSLP and E-cadherin dysfunction by PI3K/Akt signaling pathway. PMID: 28400057
12. this study shows that TSLP is a key target of Mi-2beta in keratinocytes, and that loss of TSLP signaling in regulatory T cells prevents their activation PMID: 28092372
13. These data demonstrate that multiple pathogenic strains of RSV induce IL-13-producing group 2 innate lymphoid cell proliferation and activation through a TSLP-dependent mechanism in a murine model and suggest the potential therapeutic targeting of TSLP during severe RSV infection. PMID: 27156176
14. the effects of TSLP on myeloid cells are crucial in reducing the multiple organ failure that is associated with systemic inflammation. PMID: 26934097
15. The inflammatory phenotype in barrier-defective skin is shaped by counterregulation between the TSLP/type 2 and IL-23/type 17 axes. PMID: 26993035
16. this study shows that activation of primed TH2 cells occurs independently of group 2 innate lymphoid cells or their cytokines but that the effector function of both cell types was dependent on combinatorial exposure to IL-33, IL-25 and TSLP PMID: 27749840
17. TNF-alpha and IL-1beta, which are partly produced by LPS-activated leukocytes, contribute to TSLP production via TLR4 activation in vivo. PMID: 27271511
18. IL-33-ERK/JNK/p38/Egr-1/TSLP axis involved in allergic skin Th2 inflammation PMID: 26120956
19. Suggest that TSLP may be involved in acute lung injury, and blockage of TSLP signaling using TSLPR-Ig improves ALI at least in part by regulation of dendritic cell functions. PMID: 26617780
20. TSLP expression in the skin is mediated via RARgamma-RXR pathways. PMID: 26531761
21. results highlight a previously unappreciated function of the immune system in controlling the early development of cancer and establish a fundamental role for TSLP and Th2 cells in tumor immunity against early-stage cancers. PMID: 26927668
22. Thymic stromal lymphopoietin-induced interleukin-17A is involved in the development of IgE-mediated atopic dermatitis-like skin lesions in mice PMID: 26310839
23. production by monocyte-derived dendritic cells requires the integration of signals from dectin-1, the IL-1 receptor, and endoplasmic reticulum stress response stress signaling pathways PMID: 26573878
24. The short TSLP isoform ameliorates experimental colitis in mice and prevents endotoxin shock. The long TSLP isoform is proinflammatory and is only expressed during inflammation. PMID: 26014813
25. Suggest that Treg defects in ApoE(-/-) mice might partially be attributed to the disruption of TSLP-TSLPR-LAP signaling in epithelial cells and dendritic cells. PMID: 25544178
26. expression of, and immune activation by, TSLP contributes significantly to the immunopathology of experimental autoimmune encephalomyelitis. PMID: 25753260
27. These results demonstrate a role for TSLP and IL-25 in the atopic march from skin sensitization to food allergic responses and provide a model system for the generation of potential therapeutic interventions PMID: 25365222
28. basophils and TSLP have pivotal roles in Th2 development in the skin during the sensitization phase of food allergy. PMID: 24860117
29. Thymic stromal lymphopoietin plays divergent roles in the pathogenesis of atopic and nonatopic asthma phenotypes by either enhancing Th2 responses or curtailing T-helper 17 responses. PMID: 24961817
30. TSLP signaling in CD41 T cells is required for not only TH2 memory cell formation in vivo but also the recall response of the memory cells to local antigen challenge. PMID: 25441291
31. constitutively expressed by hepatocytes and increased during halothane-induced liver injury PMID: 24723460
32. TN DC represent a dermal DC subset that should be considered in future studies of TSLP-dependent contact sensitization and skin immune responses. PMID: 25057004
33. Report glyphosphate-rich air samples stimulate airway inflammation via IL-33/TSLP/IL-13 pathways. PMID: 25172162
34. TSLP levels peak early but are sustained during the first 48 h of sepsis. PMID: 24990542
35. chronic exposure to natural airborne allergens triggers a network of innate and adaptive type 2 immune responses and airway pathology, and IL-33 and thymic stromal lymphopoietin most likely play key roles in this process. PMID: 25015831
36. Skin Tslp initiates Th2 responses through an orchestrated immune cascade. PMID: 24284909
37. plays an important role as a master switch of allergic inflammation because it promotes Th2-type immune responses by inducing the activation of dendritic cells. PMID: 24599138
38. Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoietin and IL-33. PMID: 24220317
39. Epicutaneous sensitization on a disrupted skin barrier is associated with accumulation of TSLP-elicited basophils, which are necessary and sufficient to promote antigen-induced intestinal food allergy. PMID: 24560412
40. promotes mutualistic T-cell responses following intestinal bacterial colonization PMID: 23515135
41. RG1 has the inhibitory effect of TSLP production and caspase-1 activity in AR experimental model. PMID: 24053327
42. The structure of the mouse TSLP-mediated signaling complex reveals how TSLP establishes extensive interfaces with its cognate receptor (TSLPR). PMID: 24632570
43. These results suggest that Nickel allergy may be triggered by a TSLP/TSLPR-mediated interaction between epithelial and immune cells PMID: 24670797
44. TSLP stimulation can induce cellular senescence during airway remodeling in asthma. Inhibiting the signaling pathways of cellular senescence overcomes TSLP-induced airway remodeling PMID: 24167583
45. These results indicate that the progesterone suppresses Th17 cell responses, and enhances the development of Treg cells, through TSLP-dependent mechanisms, and play a role in female asymptomatic gonococcal infections. PMID: 23835188
46. these data suggest that TSLP uniquely participates in local immunity in the respiratory tract and modulation of TSLP levels may promote long-term CD8 T cell immunity in the mucosa when other prosurvival signals are limiting. PMID: 24489089
47. Report mouse cell line producing high levels of TSLP which can be used in high-throughput screening for anti-allergy agents. PMID: 24252242
48. TSLP expression is enhanced by the absence of microbiota in mice with defective skin barriers PMID: 23698100
49. Findings show that keratinocyte-derived TSLP activates sensory neurons directly to evoke itch behaviors. PMID: 24094650
50. TSLP expression in CCR2-/- mice may contribute to the propensity of these mice to develop exaggerated Th2-type immune responses PMID: 23472158

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KEGG: mmu:53603

STRING: 10090.ENSMUSP00000025237

UniGene: Mm.143716