Mouse Tumor necrosis factor receptor superfamily member 9(TNFRSF9) ELISA kit

Code CSB-EL023984MO
Size 96T,5×96T,10×96T
See More Details 24T ELISA kits trial application
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Product Details

Target Name tumor necrosis factor receptor superfamily, member 9
Alternative Names Tnfrsf9 ELISA Kit; Cd137 ELISA Kit; Ila ELISA Kit; Ly63 ELISA Kit; Tumor necrosis factor receptor superfamily member 9 ELISA Kit; 4-1BB ligand receptor ELISA Kit; T-cell antigen 4-1BB ELISA Kit; CD antigen CD137 ELISA Kit
Abbreviation TNFRSF9
Uniprot No. P20334
Species Mus musculus (Mouse)
Detection Range Request Information
Sensitivity Request Information
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Others
and FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 7-14 working days

Target Data

Function Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Gene References into Functions
  1. m4-1BBL and Gal-9 act together to aid aggregation of m4-1BB monomers to efficiently initiate m4-1BB signaling. PMID: 29242193
  2. the CD137-CD137L pathway plays an important role in regulating VSMC phenotype transformation via activation of NFATc1 signaling pathway. PMID: 28770466
  3. Tonic 4-1BB costimulation in chimeric antigen receptors impedes T cell survival and is vector-dependent. PMID: 28978471
  4. fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8(+) T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. PMID: 26972770
  5. CD137 signaling activates the pro-angiogenic Smad1/5 pathway, induces the phosphorylation of Smad1/5 and nuclear translocation of p-Smad1/5, which in turn promotes the expression and translocation of NFATc1. Blocking CD137 signaling with inhibitory anti-CD137 antibody could inhibit this activation and attenuated agonist anti-CD137 antibody-induced angiogenesis. PMID: 28288971
  6. the role of CD137-CRDI (cysteine rich domain I) in the binding of CD137-CD137L was further investigated. PMID: 27430526
  7. Data indicate that anti-CD137 agonists can function as inhibitors of CD137L signaling, resulting in the creation of tumor microenvironments unfavorable for tumor immune evasion. PMID: 28923858
  8. This study discovers the 4-1BB pathway signaling enhances inflammatory response and promotes pulmonary fibrosis induced by crystalline silica. PMID: 27698940
  9. Constitutive interaction between 4-1BB and 4-1BBL on murine LPS-activated bone marrow dendritic cells masks detection of 4-1BBL by TKS-1 but not 19H3 antibody. PMID: 28789924
  10. results indicate that one important diabetogenic function of CD137 is to promote the expansion and accumulation of beta cell-autoreactive CD8 T cells, and in the absence of CD137 or its interaction with CD137 ligand, type 1 diabetes progression is suppressed PMID: 28363905
  11. High CD137 expression is associated with neoplasms. PMID: 28082401
  12. Ly6C, 4-1BB, and KLRG1 have roles in the activation of lamina propria lymphocytes in the small intestine in a mouse model of Crohn's disease PMID: 28011265
  13. CD137 Regulates NFATc1 Expression in Mouse VSMCs through TRAF6/NF-kappaB p65 Signaling Pathway. PMID: 26600673
  14. 4-1BB triggering preferentially enhances the expansion of CD8+ T cells through the amplification of autocrine IL-2/IL-2R signaling loop. PMID: 25962156
  15. c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival. PMID: 26096449
  16. we conclude that in vivo 4-1BB signaling of myeloid cells negatively regulates peripheral T cell responses PMID: 25601928
  17. activation of CD137 signaling decreases the stability of advanced atherosclerotic plaques via its combined effects on Teff cells, vascular smooth muscle cells, and macrophages PMID: 25059229
  18. 4-1BB mediates the inflammatory responses in obese skeletal muscle by interacting with its ligand 4-1BBL on macrophages. PMID: 24453430
  19. CD137-CD137L interactions mediated via regulation of CyPA contribute to the progression of atherosclerosis. PMID: 24520398
  20. action of agonist anti-4-1BB in suppressing autoimmune and allergic inflammation was completely dependent on Galectin-9 (Gal-9). Gal-9 directly bound to 4-1BB, in a site distinct from the binding site of antibodies and the natural ligand of 4-1BB PMID: 24958847
  21. sCD137 can actively suppress highly purified CD4 T cells in a CD137L dependent fashion. PMID: 24145149
  22. monocytes interact with iNKT cells to increase expression of 4-1BBL and 4-1BB, and in conjunction with this pathway, maintain their numbers at baseline. PMID: 24639347
  23. 4-1BB signaling enhances the proliferation of activated CD8(+) T cells. PMID: 23874982
  24. Results found the activation of CD137L reverse signaling by CD137 resulted in a decrease in cell adhesion to the fibronectin-coated culture basement, thus causing detachment-induced cell death. PMID: 23925549
  25. CD137 plays an essential role in the resolution of acute DSS-induced intestinal inflammation in mice PMID: 24023849
  26. During CD134 plus CD137 dual costimulation, IFN-gamma interacts with IL-2 through distinct mechanisms to program maximal expression of effector molecules in antigen-responding T-cells. PMID: 23295363
  27. Sjogren's syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand. PMID: 23301790
  28. Taken together, these data provide evidence that the 4-1BB signal is an important regulator of gammadelta T cells PMID: 23640752
  29. CD137-CD137L interactions increase myelopoiesis during infection PMID: 23519951
  30. 4-1BB/4-1BBL-mediated bidirectional signaling in adipocytes/macrophages promotes adipose inflammation. PMID: 23316108
  31. TRAF1 and LSP1 cooperate downstream of 4-1BB to activate ERK signaling and down-modulate the levels of Bim leading to enhanced T cell survival. PMID: 23446150
  32. The CD137 receptor/ligand system may be a mediator of neuroinflammatory and neurodegenerative disease, by activating microglia which in turn kill oligodendrocytes. PMID: 22799524
  33. Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin. PMID: 23547098
  34. 4-1BB signaling plays a role in activating maternal CD8+ T cells from their hypo-responsiveness that are reactive with allogeneic fetal tissue and probably with conventional antigens. PMID: 23029041
  35. CD137L regulates many functions of myelin oligodendrocyte glycoprotein-specific T-cells that contribute to Experimental autoimmune encephalomyelitis PMID: 23238738
  36. After stimulation of total mononuclear cells or CD4+ T cells, surface expression of 4-1BB can be used to detect activated Foxp3+ regulatory T cells (Treg) within a defined window. PMID: 23162126
  37. Results indicate that 4-1BBL/4-1BB contributes to cell survival during antigen-independent IL-2/mAb-complex-dependent T-cell expansion. PMID: 21946662
  38. Data indicate that hypoxia as sensed by the HIF-1alpha system increases expression of CD137 on tumor-infiltrating lymphocytes that become selectively responsive to the immunotherapeutic effects of anti-CD137 agonist monoclonal antibodies. PMID: 22719018
  39. deficiency does not affect development of airway inflammation or respiratory tolerance induction PMID: 22519594
  40. CD137 has a role in breast cancer and its specific antibody can be used to enhance trastuzumab efficacy PMID: 22326955
  41. conditioned medium from Lewis Lung Carcinoma cells caused significant upregulation of 4-1BB in mast cells PMID: 22343053
  42. these data demonstrate that 4-1BB and 4-1BBL do not play a strong or dominant role in driving the generation of high frequencies of vaccinia virus -specific CD8 T cells. PMID: 22037570
  43. The findings suggest that 4-1BB and 4-1BBL may be useful therapeutic targets for combating obesity-induced inflammation and metabolic disorders. PMID: 21998397
  44. the therapeutic outcome of 4-1BB triggering is determined by whether the protective immunity generated against the virus was beneficially altered by the 4-1BB triggering. PMID: 21700476
  45. T-cell co-inhibitory blockade combined with alphaCTLA-4 and active co-stimulation with alpha4-1BB promotes rejection of B16 melanoma in with a vaccine; KLRG1 is a useful marker for monitoring the anti-tumor immune response elicited by this therapy PMID: 21559358
  46. the current study identifies for the first time a specific CD134 plus CD137 costimulatory pathway and an intracellular mechanism relying on Eomesodermin that induces cytotoxic CD4 Th1 cells PMID: 21880986
  47. Membrane and soluble forms of Tnfrsf9 are expressed in specific cell types of the uterus and conceptus during the progression of implantation in mice and possibly have an important function in this process. PMID: 21560035
  48. 4-1BB signaling seems to modulate autoimmune encephalitis by a number of mechanisms, and modulation of the T helper (Th)17 cell versus regulatory T cell (Treg) balance is one of those mechanisms. PMID: 21715692
  49. 4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection. PMID: 21742975
  50. granulocyte and macrophage populations of murine bone marrow cells are regulated by G-CSF and CD137 protein PMID: 21179444
  51. These results reveal 4-1BB also has a negative regulation system through soluble 4-1BB produced from a splice variant induced under activation conditions. PMID: 21347708
  52. involvement of the cytokine receptor CD137 in hematopoiesis PMID: 21153341
  53. Results suggest with a two-step model of M cell differentiation, with initial CD137-independent commitment to the M cell lineage followed by CD137-CD137L interaction of M cells with CD137-activated B cells or dendritic cells for functional maturation. PMID: 20616340
  54. CD137-mediated pathogenesis from chronic hepatitis to hepatocellular carcinoma in hepatitis B virus-transgenic mice. PMID: 21059892
  55. induces human monocyte to dendritic cell differentiation PMID: 20432236
  56. These results suggest that a specific antitumor immune response is enhanced by DNA vaccines expressing 4-1BBL PMID: 20452657
  57. 4-1BB signaling results in a shift of the dominant type of immune cell in antitumor immunity from the innate natural killer (NK) cell to the adaptive CD8-positive T cell. The level of IFN-gamma is critical for this 4-1BB-mediated shift. PMID: 20610645
  58. selective expression of 4-1BB only on CD8(+) T cells in mice developing a massive, non-protective IFN-gamma response opens novel strategies for intervention in tuberculosis pathology and vaccination through T-cell co-stimulatory-based molecular targeting PMID: 20544034
  59. CD137 signaling in dendritic cells can regulate CD8-positive T cell survival through a Stat3- and Fas-mediated pathway. PMID: 20351189
  60. CD137 and CD28 can promote bcl-2 expression at both mRNA and protein level in T cells. PMID: 17884794
  61. The CD137/CD137 ligand signaling plays multiple roles in the progression of atherosclerosis. PMID: 20176988
  62. 4-1BB and 4-1BBL were present in the normal thymus and were preferentially expressed in the regenerating thymus, mainly in CD4(+)CD8(+) double-positive thymocytes. PMID: 19745604
  63. 4-1BB contributes to clonal expansion, survival, and development of Tc1 cells when protein antigen is encountered by primary CD8 T cells in an inflammatory environment in vivo PMID: 11828369
  64. A role for 4-1BB in dendritic cell activation PMID: 11867564
  65. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. PMID: 11877473
  66. The powerful effects of 4-1BB triggering on the induction, amplification, and persistence of tumor-specific CTL responses provide a novel strategy for increasing the potency of vaccines against cancers. PMID: 11937526
  67. expression of functional CD137 receptor by dendritic cells PMID: 11970964
  68. 4-1BB-like mRNA is detected in phorbol myristic acetate-treated spleen and heart, constitutively in the brain, kidneys and lungs and is expressed on mononuclear cells infiltrating islet cells in the pancreata. PMID: 11991655
  69. In vivo CD137 stimulation enhances and broadens the CD8+ T cell response to influenza virus and can restore the CD8+ T cell response when CD28 costimulation is absent. PMID: 12021777
  70. Treatment of tumor-bearing mice with agonistic 4-1BB-specific Abs can lead to T cell-mediated tumor rejection. PMID: 12165501
  71. CD137 is a stimulatory receptor for NK cells involved in the crosstalk between innate and adaptive immunity but does not enhance cytolytic activity of NK cells. PMID: 12370353
  72. 4-1BB-stimulated expression of Bcl-xL and Bfl-1 occurs mainly through NF-kappa B activation, a mechanism that accounts for 4-1BB-mediated long-term survival of CD8+ T lymphocytes in vivo. PMID: 12391199
  73. Targeting the T cell-expressed membrane molecule 4-1BB can synergize in vivo with endogenously produced signals and effectively overcome deficient priming of T cells in aged animals. PMID: 12391215
  74. demonstrate a stimulatory role for endogenous 4-1BB-4-1BBL interactions in the in vivo polysaccharide-specific Ig isotype response to intact S. pneumoniae PMID: 12496166
  75. 4-1BB has a role in allograft rejection and in regulating other important steps in the immune response such as the migration of T cells and dendritic cells PMID: 12752310
  76. In a murine model, absence of the 4-1BB signal appears to produce a dual effect: blocking T cell migration from the regional lymph nodes to the corneal stroma and inhibiting inflammatory responses in the corneal stroma. PMID: 12847221
  77. 4-1BB-mediated cell cycle progression of CD8(+) T cells PMID: 12884287
  78. ligation of CD137 receptor delivers a regulatory signal for T-cell anergy PMID: 12969968
  79. although 4-1BB is expressed on regulatory T cells (Tr), its contribution to their proliferation is minimal; signaling through the 4-1BB receptor inhibited the suppressive function of Tr cells in vitro and in vivo. PMID: 14694186
  80. There is a switch in costimulatory requirement from CD28 to 4-1BB during primary vs recall responses of CD8 T cells to influenza virus in vivo. PMID: 14707071
  81. 4-1BB (CD137), a member of the tumor necrosis factor-alpha receptor family, was found to be one of the up-regulated genes in bacterial infections of osteoblast cells PMID: 14729681
  82. Data demonstrate that CD4+CD25+ regulatory T cells are critical for immune tolerance induction to experimental autoimmune thyroiditis, and that induction of tolerance is inhibited by monoclonal antibodies to CD137. PMID: 14746804
  83. role in increasing antitumor immunity in CD83-expressing melanoma cells PMID: 15051893
  84. the 4-1BB costimulator receptor induces the proliferation of the CD4(+)CD25(+) regulatory T cells both in culture and in vivo. PMID: 15294956
  85. CD137-directed natural killer (NK)/NKT cells play an important role in the inflammatory response leading to the production of proinflammatory cytokines, lipopolysaccharide-induced septic shock, and tumor killing, as well as IL-4-dependent Th2 responses. PMID: 15356173
  86. 4-1BB is expressed on different T cell subsets or at different times in vivo and acts independently and nonredundantly to promote robust CD8 T cell secondary responses. PMID: 15528328
  87. Administration of multiple immunizations in combination with the costimulatory agonist ant-4-1BB enhanced the immune responses, resulting in complete tumor rejection if the tumor burden. PMID: 15856473
  88. The absence of 4-1BB can make CD4 T cells hyperresponsive to protein antigen in vivo and suggests a new unappreciated negative regulatory role of 4-1BB when expressed on a T cell. PMID: 15905521
  89. 4-1BB signaling pathway could have a primary function in the etiology of autoimmune disease PMID: 15998581
  90. CD137 engagement reduces follicular dendritic cell networks in a T cell-dependent manner. PMID: 16002686
  91. 4-1BB(+/+) mice with melanoma survived longer than 4-1BB(-/-) mice, and survival was further prolonged by triggering 4-1BB with an agonistic mAb PMID: 16033529
  92. During influenza A virus infection, formation of the same CD8+ memory T cell pool as well as its capacity for secondary expansion depend on the complementary contributions of 4-1BB, CD27, and OX40. PMID: 16034107
  93. FcepsilonRI-inducible 4-1BB plays a costimulatory function together with FcepsilonRI stimulation PMID: 16123219
  94. Involvement of 4-1BB in the development of experimental allergic conjunctivitis is investigated by studying the effect of agonistic anti-4-1BB antibodies during either the induction or effector phase of the disease PMID: 16210591
  95. Our work establishes CD137 as a candidate gene for control of autoantibody production in NOD.Idd9.3 congenic mice. PMID: 16425035
  96. 4-1BB-induced IL-13 expression is partially responsible for the CD8+ T cell expansion in an autocrine or paracrine manner PMID: 16488622
  97. Expression on memory CD8+ T cells, perhaps due to encounter with IL-15 in the bone marrow, allows 4-1BB/4-1BBL interactions to maintain memory CD8 T cell survival in the absence of Ag. PMID: 16493029
  98. 4-1BB stimulation enhanced both primary and memory anti-herpesvirus-1 CD8+ T cell responses, which was mediated by a massive expansion of antigen-specific CD11c+CD8+ T cells PMID: 16524567
  99. A novel pathway is identified that inhibits T-helper (Th) type 2 cell responses in a CD137-dependent fashion. PMID: 16818735
  100. Interaction of 4-1BB and 4-1BBL stimulates IL-10 production through 4-1BBL signaling. PMID: 17002586

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Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Expressed on the surface of activated T-cells.
Database Links

KEGG: mmu:21942

STRING: 10090.ENSMUSP00000030808

UniGene: Mm.244187

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